Localization of beta-defensin genes in non human primates.

M. Ventura, M. Boniotto, M. Pazienza, V. Palumbo, M. F. Cardone, M. Rocchi, A. Tossi, A. Amoroso, S. Crovella

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Defensins are a family of host defence peptides that play an important role in the innate immunity of mammalian and avian species. In humans, four beta-defensins have been isolated so far, corresponding to the products of the genes DEFB1 (h-BD1, GenBank accession number NM_005218); DEFB4 (h-Bd2, NM_004942.2), DEFB103 (h-BD3, NM_018661); and DEFB104 (hBD4, NM_080389) mapping on chromosome 8p23.22. We have localized beta-defensin genes on metaphasic chromosomes of great apes and several non-human primate species to determine their physical mapping. Using fluorescent in situ hybridization and BAC probes containing the four beta-defensin genes, we have mapped the homologous regions to the beta-defensin genes on chromosome 8p23-p.22 in non-human primates, while no signals were detected on prosimians chromosomes.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalEuropean journal of histochemistry : EJH
Volume48
Issue number2
Publication statusPublished - Apr 2004

Fingerprint

beta-Defensins
Primates
chromosomes
Chromosomes
Genes
genes
Strepsirhini
Defensins
physical chromosome mapping
Chromosome Mapping
Nucleic Acid Databases
Hominidae
Pongidae
fluorescence in situ hybridization
Fluorescence In Situ Hybridization
Innate Immunity
peptides
Peptides

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Cell Biology
  • Developmental Biology
  • Anatomy

Cite this

Ventura, M., Boniotto, M., Pazienza, M., Palumbo, V., Cardone, M. F., Rocchi, M., ... Crovella, S. (2004). Localization of beta-defensin genes in non human primates. European journal of histochemistry : EJH, 48(2), 185-190.

Localization of beta-defensin genes in non human primates. / Ventura, M.; Boniotto, M.; Pazienza, M.; Palumbo, V.; Cardone, M. F.; Rocchi, M.; Tossi, A.; Amoroso, A.; Crovella, S.

In: European journal of histochemistry : EJH, Vol. 48, No. 2, 04.2004, p. 185-190.

Research output: Contribution to journalArticle

Ventura, M, Boniotto, M, Pazienza, M, Palumbo, V, Cardone, MF, Rocchi, M, Tossi, A, Amoroso, A & Crovella, S 2004, 'Localization of beta-defensin genes in non human primates.', European journal of histochemistry : EJH, vol. 48, no. 2, pp. 185-190.
Ventura M, Boniotto M, Pazienza M, Palumbo V, Cardone MF, Rocchi M et al. Localization of beta-defensin genes in non human primates. European journal of histochemistry : EJH. 2004 Apr;48(2):185-190.
Ventura, M. ; Boniotto, M. ; Pazienza, M. ; Palumbo, V. ; Cardone, M. F. ; Rocchi, M. ; Tossi, A. ; Amoroso, A. ; Crovella, S. / Localization of beta-defensin genes in non human primates. In: European journal of histochemistry : EJH. 2004 ; Vol. 48, No. 2. pp. 185-190.
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