Localization of bombesin and GRP (gastrin releasing peptide) sequences in gut nerves or endocrine cells

R. Buffa, I. Solovieva, R. Fiocca, S. Giorgino, G. Rindi, E. Solcia, T. Mochizuchi, C. Yanaihara, N. Yanaihara

Research output: Contribution to journalArticle

Abstract

Five anti-gastrin releasing peptide (GRP) sera have been characterized against GRP, bombesin and related polypeptides spotted on cellulose acetate discs. Antibodies reacting with the C-terminal G-14 sequence of bombesin and the 19-27 sequence of GRP, were detected in all sera. Antibodies directed exclsively against the bombesin unrelated 1-17 sequence of GRP were found only in one serum (R-6902). With parallel immunohistochemical tests only the C-terminal immunoreactivity was detected in endocrine-paracrine cells of the chicken proventriculus, while both immunoreactivities were present in nerve fibres and a few nerve cell bodies of the mammalian gut. The distribution of GRP- and bombesin-like immunoreactive nerves in the gastric mucosa of both pyloric and oxyntic type the submucosal and myenteric plexus along the whole gastrointestinal wall and at sphincter regions is detailed.

Original languageEnglish
Pages (from-to)457-467
Number of pages11
JournalHistochemistry
Volume76
Issue number4
DOIs
Publication statusPublished - Dec 1982

ASJC Scopus subject areas

  • Anatomy

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    Buffa, R., Solovieva, I., Fiocca, R., Giorgino, S., Rindi, G., Solcia, E., Mochizuchi, T., Yanaihara, C., & Yanaihara, N. (1982). Localization of bombesin and GRP (gastrin releasing peptide) sequences in gut nerves or endocrine cells. Histochemistry, 76(4), 457-467. https://doi.org/10.1007/BF00489901