Abstract
The effect of selective destruction of serotonin (5-HT)-containing neurons with 5,7-dihydroxytryptamine (5,7-DHT) on [3H]muscimol and (-)-[3H]baclofen binding was investigated in various rat brain regions. Ten days after intracerebroventricular 5,7-DHT, serotonin levels and [3H]imipramine binding were markedly decreased. 5,7-DHT reduced [3H]muscimol binding only in the mesencephalon, and (-)-[3H]baclofen binding was unmodified in all the areas considered. These results suggest that except in the mesencephalon GABA receptors may not be localized on serotonergic nerve terminals.
Original language | English |
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Pages (from-to) | 372-375 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 371 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 23 1986 |
Keywords
- 5,7-dihydroxytryptamine lesion
- baclofen binding
- GABA receptor
- GABA receptor
- imipramine binding
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)