Localization of GABAA and GABAB receptor subtypes on serotonergic neurons

T. Mennini; M. Gobbi; S. Romandini

doi:10.1016/0006-8993(86)90378-1

Localization of GABAA and GABAB receptor subtypes on serotonergic neurons

T. Mennini, M. Gobbi, S. Romandini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of selective destruction of serotonin (5-HT)-containing neurons with 5,7-dihydroxytryptamine (5,7-DHT) on [³H]muscimol and (-)-[³H]baclofen binding was investigated in various rat brain regions. Ten days after intracerebroventricular 5,7-DHT, serotonin levels and [³H]imipramine binding were markedly decreased. 5,7-DHT reduced [³H]muscimol binding only in the mesencephalon, and (-)-[³H]baclofen binding was unmodified in all the areas considered. These results suggest that except in the mesencephalon GABA receptors may not be localized on serotonergic nerve terminals.

Original language	English
Pages (from-to)	372-375
Number of pages	4
Journal	Brain Research
Volume	371
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(86)90378-1
Publication status	Published - Apr 23 1986

Keywords

5,7-dihydroxytryptamine lesion
baclofen binding
GABA receptor
GABA receptor
imipramine binding

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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title = "Localization of GABAA and GABAB receptor subtypes on serotonergic neurons",

abstract = "The effect of selective destruction of serotonin (5-HT)-containing neurons with 5,7-dihydroxytryptamine (5,7-DHT) on [3H]muscimol and (-)-[3H]baclofen binding was investigated in various rat brain regions. Ten days after intracerebroventricular 5,7-DHT, serotonin levels and [3H]imipramine binding were markedly decreased. 5,7-DHT reduced [3H]muscimol binding only in the mesencephalon, and (-)-[3H]baclofen binding was unmodified in all the areas considered. These results suggest that except in the mesencephalon GABA receptors may not be localized on serotonergic nerve terminals.",

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author = "T. Mennini and M. Gobbi and S. Romandini",

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AU - Mennini, T.

AU - Gobbi, M.

AU - Romandini, S.

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N2 - The effect of selective destruction of serotonin (5-HT)-containing neurons with 5,7-dihydroxytryptamine (5,7-DHT) on [3H]muscimol and (-)-[3H]baclofen binding was investigated in various rat brain regions. Ten days after intracerebroventricular 5,7-DHT, serotonin levels and [3H]imipramine binding were markedly decreased. 5,7-DHT reduced [3H]muscimol binding only in the mesencephalon, and (-)-[3H]baclofen binding was unmodified in all the areas considered. These results suggest that except in the mesencephalon GABA receptors may not be localized on serotonergic nerve terminals.

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