Localization of GABAA and GABAB receptor subtypes on serotonergic neurons

T. Mennini, M. Gobbi, S. Romandini

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of selective destruction of serotonin (5-HT)-containing neurons with 5,7-dihydroxytryptamine (5,7-DHT) on [3H]muscimol and (-)-[3H]baclofen binding was investigated in various rat brain regions. Ten days after intracerebroventricular 5,7-DHT, serotonin levels and [3H]imipramine binding were markedly decreased. 5,7-DHT reduced [3H]muscimol binding only in the mesencephalon, and (-)-[3H]baclofen binding was unmodified in all the areas considered. These results suggest that except in the mesencephalon GABA receptors may not be localized on serotonergic nerve terminals.

Original languageEnglish
Pages (from-to)372-375
Number of pages4
JournalBrain Research
Volume371
Issue number2
DOIs
Publication statusPublished - Apr 23 1986

Keywords

  • 5,7-dihydroxytryptamine lesion
  • baclofen binding
  • GABA receptor
  • GABA receptor
  • imipramine binding

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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