Localization of mitochondrial DNA in normal and pathological muscle using immunological probes: A new approach to the study of mitochondrial myopathies

Francesca Andreetta, Hans Jurgen Tritschler, Eric A. Schon, Salvatore DiMauro, Eduardo Bonilla

Research output: Contribution to journalArticle

Abstract

We have studied the usefulness of anti-DNA antibodies to detect ragged-red fibers (RRF) in muscle biopsies from patients with mitochondrial myopathies. We have found that these antibodies are excellent probes for the localization of mitochondrial DNA (mtDNA) in RRF, and for the diagnosis of depletion of mtDNA in a newly described group of fatal myopathies of infancy.

Original languageEnglish
Pages (from-to)88-92
Number of pages5
JournalJournal of the Neurological Sciences
Volume105
Issue number1
DOIs
Publication statusPublished - 1991

Keywords

  • Anti-DNA
  • Mitochondrial myopathies
  • mtDNA antibody

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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