Localization of MPP+ binding sites in the brain of various mammalian species

M. Del Zompo, M. P. Piccardi, S. Ruiu, A. Albanese, M. Morelli

Research output: Contribution to journalArticlepeer-review

Abstract

The distribution and density of3H-MPP+ binding sites were studied by in vitro quantitative autoradiography in the brain of the mouse, rat and monkey. The highest levels of3H-MPP+ specific binding were observed in rat brain. The substantia nigra in rat and monkey, and the anterior caudate-putamen formation in mouse and monkey showed the lowest density of autoradiographic grains. The presence of a relatively high density of MPP+ sites in the hippocampus of all species studied could be of interest to explain some effects of MPTP administration on convulsions caused by chemoconvulsants. The finding of a 60-70% reduction of3H-MPP+ binding sites in the rat caudate-putamen, on the side of quinolinic acid infusion and no changes after 6-hydroxydopamine lesion of dopaminergic nigrostriatal neurons suggests the presence of these sites mainly on striatal cells. The results suggest that the distribution of MPP+ binding sites in brain would not seem to be related to MPTP toxicity.

Original languageEnglish
Pages (from-to)181-190
Number of pages10
JournalJournal of Neural Transmission - Parkinson's Disease and Dementia Section
Volume4
Issue number3
DOIs
Publication statusPublished - Sep 1992

Keywords

  • autoradiography mammalian brain
  • binding sites
  • dopamine
  • MPP
  • neurotoxicity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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