Localization of the chemotactic domain in fibronectin

A. Albini, H. Richter, B. F. Pontz

Research output: Contribution to journalArticlepeer-review

Abstract

Fragments derived from human plasma fibronectin by enzymatic degradation were tested in the Boyden chamber for chemotactic activity towards various fibroblast strains. The results provide clear evidence that the chemotactic activity is restricted to a defined region of the fibronectin molecule which is the same for various fibroblast strains. The active domain is localized between the collagen binding site and the major heparin binding site, about 170 kDa apart from the N-terminal and about 70 kDa from the C-terminal ends of the two subunit peptide chains.

Original languageEnglish
Pages (from-to)222-226
Number of pages5
JournalFEBS Letters
Volume156
Issue number2
DOIs
Publication statusPublished - Jun 13 1983

Keywords

  • Boyden chamber
  • Fibroblast chemotaxis
  • Fibronectin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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