Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers

Emilio Donti, Luisa Lanfrancone, Kay Huebner, Anna Pascucci, Giovanna Venti, Gina Pengue, Fausto Grignani, Carlo M. Croce, Luigi Lania, Pier Giuseppe Pelicci

Research output: Contribution to journalArticle

Abstract

The finger motif is a tandemly repeated DNA-binding domain recently identified in the primary structure of several eukaryotic transcriptional regulatory proteins. It has been proposed that some members of the finger-gene family are implicated in both normal cell proliferation and differentiation. We isolated several human finger genes by means of hybridization with a finger motif-containing DNA probe. One of these finger genes, HF.10, is expressed at low levels in a variety of human tissues and is down-regulated during the in vitro terminal differentiation of human leukemic myeloid cell lines. By in situ hybridization experiments and analysis of interspecific somatic cell hybrids we mapped the HF.10 gene to 3p21-22, a chromosome region frequently involved in karyotypic rearrangements associated with lung and renal cancer.

Original languageEnglish
Pages (from-to)391-395
Number of pages5
JournalHuman Genetics
Volume84
Issue number5
DOIs
Publication statusPublished - Apr 1990

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ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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