Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers

Emilio Donti, Luisa Lanfrancone, Kay Huebner, Anna Pascucci, Giovanna Venti, Gina Pengue, Fausto Grignani, Carlo M. Croce, Luigi Lania, Pier Giuseppe Pelicci

Research output: Contribution to journalArticle

Abstract

The finger motif is a tandemly repeated DNA-binding domain recently identified in the primary structure of several eukaryotic transcriptional regulatory proteins. It has been proposed that some members of the finger-gene family are implicated in both normal cell proliferation and differentiation. We isolated several human finger genes by means of hybridization with a finger motif-containing DNA probe. One of these finger genes, HF.10, is expressed at low levels in a variety of human tissues and is down-regulated during the in vitro terminal differentiation of human leukemic myeloid cell lines. By in situ hybridization experiments and analysis of interspecific somatic cell hybrids we mapped the HF.10 gene to 3p21-22, a chromosome region frequently involved in karyotypic rearrangements associated with lung and renal cancer.

Original languageEnglish
Pages (from-to)391-395
Number of pages5
JournalHuman Genetics
Volume84
Issue number5
DOIs
Publication statusPublished - Apr 1990

Fingerprint

Fingers
Chromosomes
Genes
Neoplasms
Chromosomes, Human, Pair 22
Hybrid Cells
Kidney Neoplasms
DNA Probes
Myeloid Cells
In Situ Hybridization
Cell Differentiation
Lung Neoplasms
Cell Proliferation
Cell Line
DNA
Proteins

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers. / Donti, Emilio; Lanfrancone, Luisa; Huebner, Kay; Pascucci, Anna; Venti, Giovanna; Pengue, Gina; Grignani, Fausto; Croce, Carlo M.; Lania, Luigi; Pelicci, Pier Giuseppe.

In: Human Genetics, Vol. 84, No. 5, 04.1990, p. 391-395.

Research output: Contribution to journalArticle

Donti, E, Lanfrancone, L, Huebner, K, Pascucci, A, Venti, G, Pengue, G, Grignani, F, Croce, CM, Lania, L & Pelicci, PG 1990, 'Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers', Human Genetics, vol. 84, no. 5, pp. 391-395. https://doi.org/10.1007/BF00195806
Donti, Emilio ; Lanfrancone, Luisa ; Huebner, Kay ; Pascucci, Anna ; Venti, Giovanna ; Pengue, Gina ; Grignani, Fausto ; Croce, Carlo M. ; Lania, Luigi ; Pelicci, Pier Giuseppe. / Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers. In: Human Genetics. 1990 ; Vol. 84, No. 5. pp. 391-395.
@article{2ae95e53623e4eafb5f02b371f935553,
title = "Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers",
abstract = "The finger motif is a tandemly repeated DNA-binding domain recently identified in the primary structure of several eukaryotic transcriptional regulatory proteins. It has been proposed that some members of the finger-gene family are implicated in both normal cell proliferation and differentiation. We isolated several human finger genes by means of hybridization with a finger motif-containing DNA probe. One of these finger genes, HF.10, is expressed at low levels in a variety of human tissues and is down-regulated during the in vitro terminal differentiation of human leukemic myeloid cell lines. By in situ hybridization experiments and analysis of interspecific somatic cell hybrids we mapped the HF.10 gene to 3p21-22, a chromosome region frequently involved in karyotypic rearrangements associated with lung and renal cancer.",
author = "Emilio Donti and Luisa Lanfrancone and Kay Huebner and Anna Pascucci and Giovanna Venti and Gina Pengue and Fausto Grignani and Croce, {Carlo M.} and Luigi Lania and Pelicci, {Pier Giuseppe}",
year = "1990",
month = "4",
doi = "10.1007/BF00195806",
language = "English",
volume = "84",
pages = "391--395",
journal = "Human Genetics",
issn = "0340-6717",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers

AU - Donti, Emilio

AU - Lanfrancone, Luisa

AU - Huebner, Kay

AU - Pascucci, Anna

AU - Venti, Giovanna

AU - Pengue, Gina

AU - Grignani, Fausto

AU - Croce, Carlo M.

AU - Lania, Luigi

AU - Pelicci, Pier Giuseppe

PY - 1990/4

Y1 - 1990/4

N2 - The finger motif is a tandemly repeated DNA-binding domain recently identified in the primary structure of several eukaryotic transcriptional regulatory proteins. It has been proposed that some members of the finger-gene family are implicated in both normal cell proliferation and differentiation. We isolated several human finger genes by means of hybridization with a finger motif-containing DNA probe. One of these finger genes, HF.10, is expressed at low levels in a variety of human tissues and is down-regulated during the in vitro terminal differentiation of human leukemic myeloid cell lines. By in situ hybridization experiments and analysis of interspecific somatic cell hybrids we mapped the HF.10 gene to 3p21-22, a chromosome region frequently involved in karyotypic rearrangements associated with lung and renal cancer.

AB - The finger motif is a tandemly repeated DNA-binding domain recently identified in the primary structure of several eukaryotic transcriptional regulatory proteins. It has been proposed that some members of the finger-gene family are implicated in both normal cell proliferation and differentiation. We isolated several human finger genes by means of hybridization with a finger motif-containing DNA probe. One of these finger genes, HF.10, is expressed at low levels in a variety of human tissues and is down-regulated during the in vitro terminal differentiation of human leukemic myeloid cell lines. By in situ hybridization experiments and analysis of interspecific somatic cell hybrids we mapped the HF.10 gene to 3p21-22, a chromosome region frequently involved in karyotypic rearrangements associated with lung and renal cancer.

UR - http://www.scopus.com/inward/record.url?scp=0025266822&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025266822&partnerID=8YFLogxK

U2 - 10.1007/BF00195806

DO - 10.1007/BF00195806

M3 - Article

C2 - 2108922

AN - SCOPUS:0025266822

VL - 84

SP - 391

EP - 395

JO - Human Genetics

JF - Human Genetics

SN - 0340-6717

IS - 5

ER -