The finger motif is a tandemly repeated DNA-binding domain recently identified in the primary structure of several eukaryotic transcriptional regulatory proteins. It has been proposed that some members of the finger-gene family are implicated in both normal cell proliferation and differentiation. We isolated several human finger genes by finger-motif-containing DNA probe hybridization and mapped four of them to human chromosomes by in situ hybridization. Three of these genes were localized on chromosomal regions involved in specific deletions associated with human neoplasias. In particular HF.2 finger gene is located on the 1p34p35 band characteristically lost in human neuroblastoma.
|Number of pages||3|
|Journal||Clinical Chemistry and Enzymology Communications|
|Publication status||Published - 1990|
ASJC Scopus subject areas
- Clinical Biochemistry