Localization of the human HF.2 finger gene on the band 1p34p35 deleted in neuroblastoma tumor

E. Donti, L. Longo, L. Lanfrancone, G. P. Tonini, A. Pascucci, F. Grignani, L. Lania, P. G. Pelicci

Research output: Contribution to journalArticle

Abstract

The finger motif is a tandemly repeated DNA-binding domain recently identified in the primary structure of several eukaryotic transcriptional regulatory proteins. It has been proposed that some members of the finger-gene family are implicated in both normal cell proliferation and differentiation. We isolated several human finger genes by finger-motif-containing DNA probe hybridization and mapped four of them to human chromosomes by in situ hybridization. Three of these genes were localized on chromosomal regions involved in specific deletions associated with human neoplasias. In particular HF.2 finger gene is located on the 1p34p35 band characteristically lost in human neuroblastoma.

Original languageEnglish
Pages (from-to)243-245
Number of pages3
JournalClinical Chemistry and Enzymology Communications
Volume2
Issue number4-6
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Clinical Biochemistry

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