Localization of the human phosphotyrosine phosphatase-related genes (h-PRL-1) to chromosome bands 1p35-p34, 17q12-q21, 11q24-q25 and 12q24

Marco Montagna, Olga Serova, Bakary S. Sylla, M. G. Mattei, Gilbert M. Lenoir

Research output: Contribution to journalArticle

Abstract

The h-PRL-1 gene codes for a new phosphotyrosine phosphatase that may play an important role in the control of basic cellular processes such as cell growth and proliferation. Using the cDNA of the h-PRL-1 gene as a probe, we examined a somatic mouse and hamster x human hybrid panel and found that chromosomes 1, 17 and 11 harbor sequences homologous to h-PRL-1. By in situ hybridization of metaphase spreads, subchromosomal localizations were determined at bands 1p35-p34, 17q12-q21 and 11q24-q25; in addition, a faint signal was detected at 12q24. The chromosomal assignment of the genes homologous to h-PRL-1 will help the investigation of its possible involvement in human diseases involving genetic alteration at these chromosomal regions.

Original languageEnglish
Pages (from-to)738-740
Number of pages3
JournalHuman Genetics
Volume98
Issue number6
DOIs
Publication statusPublished - Dec 1996

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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