Localized amyloidosis and gastrointestinal lymphoma: A rare association

G. Goteri, R. Ranaldi, S. A. Pileri, I. Bearzi

Research output: Contribution to journalArticle

Abstract

Aims: Five cases of primary gastrointestinal (GI) lymphoma (three in the stomach, one in the ileum (IPSID) and one in the colon) associated with localized AL amyloidosis were studied to identify morphological or immunohistochemical features which could explain the amyloid deposition. Methods and results: All the cases were low-grade marginal zone B-cell lymphomas; one case of gastric lymphoma and the IPSID also had a high-grade component. The lymphomas had a monoclonal plasma cell population, with different light and heavy-chain type expression in the five cases. Plasma cell differentiation was closely associated with the amyloid deposits. The latter were an incidental microscopic finding in one case, but produced tumoral masses in the others. Conclusions: The presence of amyloid in primary GI lymphoma is rare, but can have diagnostic value. In the present study, neither particular features of the lymphomatous proliferation nor specific agents are identified. Therefore, the factors predisposing to amyloid deposition require elucidation.

Original languageEnglish
Pages (from-to)348-355
Number of pages8
JournalHistopathology
Volume32
Issue number4
DOIs
Publication statusPublished - 1998

Keywords

  • Amyloid
  • Gastrointestinal tract
  • MALT lymphoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

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