Localized hand-foot syndrome after intra-arterial hepatic chemotherapy with floxuridine: A clinical case

Claudia Bareggi, Daniela Paleari, Marina Chiara Garassino, Monica Mora, Silvia Salamina, Monica Senecione, Antonio Ghidini, Gianfranco Pancera

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Abstract

Hand-foot syndrome is a toxic effect of some chemotherapy agents such as 5-fluorouracil (5-FU), capecitabine and liposomal doxorubicin. The symptoms and signs are localized erythema and paresthesia. Floxuridine (FUDR) is an analogue of 5-FU, used for arterial hepatic infusion in patients affected by liver metastases from colorectal cancer. A patient who was treated for colorectal cancer with liver metastases underwent locoregional chemotherapy with FUDR and systemic chemotherapy with FOLFOX4. After three cycles he developed severe painful dermatitis of the right leg. Abdominal X-ray showed displacement of the catheter to the right common iliac artery. Treatment was discontinued and the patient had a rapid recovery.

Original languageEnglish
Pages (from-to)193-196
Number of pages4
JournalTumori
Volume91
Issue number2
Publication statusPublished - Mar 2005

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Keywords

  • Arterial hepatic infusion
  • Floxuridine
  • Hand-foot syndrome

ASJC Scopus subject areas

  • Cancer Research

Cite this

Bareggi, C., Paleari, D., Garassino, M. C., Mora, M., Salamina, S., Senecione, M., Ghidini, A., & Pancera, G. (2005). Localized hand-foot syndrome after intra-arterial hepatic chemotherapy with floxuridine: A clinical case. Tumori, 91(2), 193-196.