Sclerodermia localizzata o morfea nel paziente pediatrico

Translated title of the contribution: Localized scleroderma or morphea in childhood

Mauro Paradisi, A. Provini, C. Pedicelli, G. Palermi, C. Angelo, O. De Pità

Research output: Contribution to journalArticle

Abstract

Scleroderma is a disease of unknown origin, characterized by thickening and induration of the skin, involving, in many cases, internal organs. Two main types are clinically observed: systemic sclerosis, a progressive and multisystemic disorder, and localized scleroderma (morphea), in which sclerosis is limited to the skin. Main subtypes of morphea are: circumscribed, guttate, linear, nodular and profunda. The commonest form of scleroderma in childhood is morphea, and among this, linear lesions are the most frequent. These can be divided in 4 subtypes. 1) lesions involving the limbs, 2) the form so called "en coupe de sabre" (of the face), 3) Parry-Romberg syndrome (hemifacial atrophy), and 4) disabling pansclerotic morphea. Polimorphic clinical features and subcutaneous involvement, with atrophy and hyperpigmentation, are more common in childhood. Actually, topical steroids represent the more effective therapy, particularly in early stages of the disease. Recent studies demonstrated that for its immunomodulating and antifibrotic properties calcitriol treatment may be also attempted with encouraging results.

Translated title of the contributionLocalized scleroderma or morphea in childhood
Original languageItalian
Pages (from-to)50-55
Number of pages6
JournalProgressi in Reumatologia
Volume4
Issue number1
Publication statusPublished - 2003

ASJC Scopus subject areas

  • Rheumatology

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  • Cite this

    Paradisi, M., Provini, A., Pedicelli, C., Palermi, G., Angelo, C., & De Pità, O. (2003). Sclerodermia localizzata o morfea nel paziente pediatrico. Progressi in Reumatologia, 4(1), 50-55.