Locally advanced paranasal sinus carcinoma: A study of 30 patients

Francesco Perri, Raffaele Addeo, Manuel Conson, Adriana Faiella, Giuseppina Della Vittoria Scarpati, Gabriella Della Torre, Angela Di Biase, Paola Romanelli, Carlo Buonerba, Giuseppe Di Lorenzo, Antonio Daponte, Francesco Caponigro, Salvatore Pisconti, Roberto Pacelli, Vincenzo Ravo, Paolo Muto, Raffaele Solla

Research output: Contribution to journalArticlepeer-review

Abstract

Sinonasal carcinomas (SNcs) are rare neoplasms arising from the paranasal sinuses and nasal cavity. Although these tumours have a heterogeneous histology, they are commonly diagnosed as a locally advanced disease and are associated with a poor prognosis. The present retrospective study reviewed 30 patients with locally advanced SNc, who were treated with surgery followed by chemoradiotherapy or radiotherapy, or radiotherapy with or without concomitant chemotherapy between January 1999 and January 2013 at the Department of Radiation Therapy, University of Naples ‘Federico II’ (Naples, Italy). A total of 19 patients were treated with upfront surgery followed by adjuvant radio‑ or chemoradiotherapy (group A), while the remaining 11 patients received exclusive radiotherapy with or without concomitant chemotherapy (group B). Concurrent cisplatin‑based chemotherapy (100 mg/m2, days 1, 22 and 43 for 3 cycles) was administered to 34% of patients in group A and 55% of patients in group B. At a median follow‑up of 31 months, 33.3% of patients were alive. Cause‑specific survival (CSS) and progression‑free survival (PFS) times were 32 and 12 months, respectively. No difference in CSS rate was observed between the two treatment groups. Univariate analysis determined that disease stage was the only factor that significantly affected CSS (P=0.002) and PFS (P=0.0001) rates. Acute and chronic toxicities were mild, with only 23.3% of patients reporting G1‑2 side effects and no treatment‑related blindness. The present study reported moderate activity and efficacy of surgery followed by adjuvant radio‑ or chemoradiotherapy, and exclusive radiotherapy with or without chemotherapy in this poor prognosis category of patients.

Original languageEnglish
Pages (from-to)1338-1342
Number of pages5
JournalOncology Letters
Volume13
Issue number3
DOIs
Publication statusPublished - Mar 1 2017

Keywords

  • Chemotherapy
  • Locally advanced
  • Nasal cavity tumours
  • Paranasal sinus carcinoma
  • Radiotherapy
  • Three‑dimensional conformal radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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