Locally delivered chemotherapy and repeated surgery can improve survival in glioblastoma patients

A. Boiardi, M. Eoli, A. Pozzi, A. Salmaggi, G. Broggi, A. Silvani

Research output: Contribution to journalArticlepeer-review


We treated 54 patients, newly diagnosed for glioblastoma, with systemic chemotherapy (carmustine (BCNU) 100 mg/m2 and cisplatin 90 mg/m2 every 6 weeks) and radiotherapy soon after surgery. In 10 cases the treatment was combined with locoregional chemotherapy (1 mg bleomycin on days 1-2, and 3 mg mitoxanthrone on day 3, repeated every 20 days) administered from an Ommaya reservoir. At tumor recurrence, all patients were treated with procarbazine, lomustine and vincristine (PCV); 15 of 54 were reoperated and treated with locoregional chemotherapy. The median time to disease progression (TTP) and overall survival time (ST) for the whole group were 10.8 and 23.1 months, respectively. The ST of the 15 reoperated patients who also received locoregional treatment at disease recurrence was 27.6 months; this was significantly longer than that of patients not reoperated and not treated locally (log-rank p=0.04). The results in our reoperated subgroup support the opinion that a second operation could be suitable if it is part of the whole program of treatment.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalItalian Journal of Neurological Sciences
Issue number1
Publication statusPublished - 1999


  • Glioblastoma
  • Locoregional chemotherapy
  • Mitoxantrone

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)


Dive into the research topics of 'Locally delivered chemotherapy and repeated surgery can improve survival in glioblastoma patients'. Together they form a unique fingerprint.

Cite this