Locations of mouse DNA damage response and repair loci, and cancer risk modifiers

Robert A. Bulman; Tommaso A. Dragani; Simon D. Bouffler; Roger Cox

doi:10.1016/j.dnarep.2005.10.001

Locations of mouse DNA damage response and repair loci, and cancer risk modifiers

Robert A. Bulman, Tommaso A. Dragani, Simon D. Bouffler, Roger Cox

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

An outline is presented of an electronically accessible database that compares the locations of mouse genes involved in DNA repair, apoptosis, cell cycle and signal transduction with those of known cancer risk modifier genes. The database has a primary but not exclusive focus on modifiers of ionizing radiation (IR) cancer risk and genes involved in IR-induced DNA damage responses. The database (http://www.hpa.org.uk/radiation/publications/ misc_publications/dna_database/dna_database.htm) provides a useful tool for assessing the role of DNA damage response genes in cancer predisposition. Crown

Original language	English
Pages (from-to)	274-277
Number of pages	4
Journal	DNA Repair
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/j.dnarep.2005.10.001
Publication status	Published - Feb 3 2006

Keywords

Cancer
DNA repair
Ionizing radiation

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/j.dnarep.2005.10.001

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abstract = "An outline is presented of an electronically accessible database that compares the locations of mouse genes involved in DNA repair, apoptosis, cell cycle and signal transduction with those of known cancer risk modifier genes. The database has a primary but not exclusive focus on modifiers of ionizing radiation (IR) cancer risk and genes involved in IR-induced DNA damage responses. The database (http://www.hpa.org.uk/radiation/publications/ misc_publications/dna_database/dna_database.htm) provides a useful tool for assessing the role of DNA damage response genes in cancer predisposition. Crown",

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AU - Bulman, Robert A.

AU - Dragani, Tommaso A.

AU - Bouffler, Simon D.

AU - Cox, Roger

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AB - An outline is presented of an electronically accessible database that compares the locations of mouse genes involved in DNA repair, apoptosis, cell cycle and signal transduction with those of known cancer risk modifier genes. The database has a primary but not exclusive focus on modifiers of ionizing radiation (IR) cancer risk and genes involved in IR-induced DNA damage responses. The database (http://www.hpa.org.uk/radiation/publications/ misc_publications/dna_database/dna_database.htm) provides a useful tool for assessing the role of DNA damage response genes in cancer predisposition. Crown

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KW - Ionizing radiation

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