Loco-regional recurrence in 2064 patients with breast cancer treated with mastectomy without adjuvant radiotherapy

L. Livi, C. Saieva, B. Detti, I. Meattini, T. Susini, F. Paiar, A. Mileo, A. Rampini, A. Bruni, A. Petrucci, G. P. Biti

Research output: Contribution to journalArticle

Abstract

Introduction: We investigated the incidence of loco-regional recurrence in a sub-group of patients who underwent mastectomy without adjuvant radiotherapy to evaluate the effect of each specific clinical or pathological parameter that could be associated with a higher local relapse rate. Patients and methods: Two thousand and sixty-four patients were treated from January 1971 to December 2003 at the University of Florence. Results: At the time of analysis 18.3% of patients (378/2064) had isolated loco-regional failures. Univariate analysis showed an association of borderline statistical significance with pathological tumour size. Elderly age at diagnosis had a low incidence of local recurrence but the results did not reach statistical significant. The number of positive axillary lymph node did not show any influence for local recurrence. Conclusion: In our series we noted a higher relapse rate only related to the pathological tumour size without any correlation with number of positive axillary nodes. Radiotherapy after mastectomy still remains controversial, but in our series the number of positive axillary lymph node did not seem enough to justify adjuvant treatment.

Original languageEnglish
Pages (from-to)977-981
Number of pages5
JournalEuropean Journal of Surgical Oncology
Volume33
Issue number8
DOIs
Publication statusPublished - Oct 2007

Keywords

  • Local recurrence
  • Mastectomy
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Surgery

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    Livi, L., Saieva, C., Detti, B., Meattini, I., Susini, T., Paiar, F., Mileo, A., Rampini, A., Bruni, A., Petrucci, A., & Biti, G. P. (2007). Loco-regional recurrence in 2064 patients with breast cancer treated with mastectomy without adjuvant radiotherapy. European Journal of Surgical Oncology, 33(8), 977-981. https://doi.org/10.1016/j.ejso.2007.01.034