Loco-regional therapy and breast cancer survival: Searching for a link

Riccardo Ponzone, Michael Baum

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: The relationship between loco-regional (LR) control and breast cancer survival was investigated with the intention of generating a new biological hypothesis to explain some of the paradoxes unaccounted for by the prevailing conceptual model of the disease. Background: The progressive reduction of surgical aggressiveness has been accompanied by an increase of breast cancer survival mainly attributed to the adoption of adjuvant systemic therapies. More recently, it has been recognized that effective LR control may prolong the survival of breast cancer patients, although the reasons for this improvement have not yet been clearly defined. Methods: The literature (PubMed) was reviewed for publications related to breast cancer LR treatments using the following key words: breast cancer surgery, breast cancer radiotherapy, breast cancer loco-regional control, breast cancer survival. Results: Although breast cancer is frequently a multifocal disease, neither mastectomy nor whole breast irradiation are always mandatory to obtain adequate local control. Conversely, selected groups of patients carry a particularly elevated risk of LR relapse and require more effective treatments to be developed. True LR recurrences are associated with a decreased overall survival and this may be related to a complex relationship between circulating tumor cells, re-seeding of the primary tumor site and several metabolic effects linked to the act of surgery. Conclusion: The prevention of LR recurrences is a major goal of breast cancer care, which requires a better understanding of the complex relationships between the primary tumor and its metastatic process.

Original languageEnglish
Pages (from-to)510-514
Number of pages5
JournalBreast
Volume22
Issue number4
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Breast Neoplasms
Survival
Therapeutics
Recurrence
Circulating Neoplastic Cells
Mastectomy
PubMed
Publications
Neoplasms
Breast
Radiotherapy

Keywords

  • Breast cancer loco-regional control
  • Breast cancer radiotherapy
  • Breast cancer surgery
  • Breast cancer survival

ASJC Scopus subject areas

  • Surgery

Cite this

Loco-regional therapy and breast cancer survival : Searching for a link. / Ponzone, Riccardo; Baum, Michael.

In: Breast, Vol. 22, No. 4, 08.2013, p. 510-514.

Research output: Contribution to journalArticle

Ponzone, Riccardo ; Baum, Michael. / Loco-regional therapy and breast cancer survival : Searching for a link. In: Breast. 2013 ; Vol. 22, No. 4. pp. 510-514.
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