Loco-regional thrombolysis in the treatment of cerebral venous and sinus thrombosis

Report of two cases

G. Buccino, U. Scoditti, M. Pini, R. Menozzi, P. Piazza, P. Zuccoli, D. Mancia

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Although intravenous (i.v.) heparin is widely used as the first line treatment for cerebral venous and sinus thrombosis (CVST), the most appropriate therapy for this disease is still controversial. We report 2 cases of CVST who were successfully treated by means of loco-regional thrombolysis with urokinase. In the first case we chose this treatment instead of i.v. heparin because clinical conditions of the patient appeared critical for life on hospital admission; in the second case loco-regional thrombolysis was performed because a full-dose heparin treatment over 8 days failed to improve the clinical picture of the patient. In the literature, there are no established criteria for the use of loco-regional thrombolysis in CVST. On the basis of our own experience and few previous reports on the matter, we suggest that loco-regional thrombolysis should be considered an appropriate treatment for CVST when patients are at life risk, when an involvement of deep cerebral veins is present or when, after full heparinization, patients are doing poorly clinically.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalActa Neurologica Scandinavica
Volume103
Issue number1
DOIs
Publication statusPublished - 2001

Fingerprint

Intracranial Sinus Thrombosis
Intracranial Thrombosis
Venous Thrombosis
Heparin
Cerebral Veins
Therapeutics
Urokinase-Type Plasminogen Activator

Keywords

  • Cerebral venous and sinus thrombosis
  • rtPA
  • Thrombolysis
  • Urokinase

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Loco-regional thrombolysis in the treatment of cerebral venous and sinus thrombosis : Report of two cases. / Buccino, G.; Scoditti, U.; Pini, M.; Menozzi, R.; Piazza, P.; Zuccoli, P.; Mancia, D.

In: Acta Neurologica Scandinavica, Vol. 103, No. 1, 2001, p. 59-63.

Research output: Contribution to journalArticle

Buccino, G. ; Scoditti, U. ; Pini, M. ; Menozzi, R. ; Piazza, P. ; Zuccoli, P. ; Mancia, D. / Loco-regional thrombolysis in the treatment of cerebral venous and sinus thrombosis : Report of two cases. In: Acta Neurologica Scandinavica. 2001 ; Vol. 103, No. 1. pp. 59-63.
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