Locomotor activity pattern induced by diazepam in control and caffeine-treated mice

M. Sansone, F. Pavone, M. Battaglia, J. Vetulani

Research output: Contribution to journalArticlepeer-review


The effect of diazepam on locomotor activity was tested by measuring the number of crossings between two compartments of a toggle-floor box, in control mice (water drinking) and in mice receiving caffeine solution (0.5 g/l) instead of drinking water. In control mice, diazepam did not produce any significant change in total activity measured on the whole 60-min test, but animals showed phases of increased activity broken by periods of immobility. After chronic ingestion (18 days) of caffeine, doses of 0.5, 1 and 2 mg/kg ip diazepam significantly increased total locomotor activity. Caffeine slightly reduced diazepam-induced immobility and increased the frequency of crossings in active periods. Taken together, these two effects may explain the significant increase in total activity induced by diazepam in caffeine-treated mice. Mixed stimulatory-depressant action was also produced by 3 mg/kg diazepam, a dose that slightly decreased the total activity.

Original languageEnglish
Pages (from-to)387-392
Number of pages6
JournalPolish Journal of Pharmacology
Issue number5
Publication statusPublished - 1995


  • Caffeine
  • Diazepam
  • Locomotor activity
  • Mice

ASJC Scopus subject areas

  • Pharmacology


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