Locomotor depression by the opioid benzodiazepine tifluadom in mice

C. Castellano, F. Pavone, M. Sansone

Research output: Contribution to journalArticlepeer-review


Several doses of tifluadom, an opioid benzodiazepine with affinity for opioid κ receptors, were tested on analgesia and locomotor activity in two strains of mice, the C57BL/6 and the DBA/2. The analgesic properties of the compound were confirmed in both strains by a tail flick test. As concerns locomotor activity both strains, that in previous researches showed opposite responses to opiates, were depressed by tifluadom, suggesting the involvement of κ receptors in this effect.

Original languageEnglish
Pages (from-to)318-323
Number of pages6
JournalArchives Internationales de Pharmacodynamie et de Therapie
Issue number2
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pharmacology


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