Locomotor depression by the opioid benzodiazepine tifluadom in mice

C. Castellano; F. Pavone; M. Sansone

Locomotor depression by the opioid benzodiazepine tifluadom in mice

C. Castellano, F. Pavone, M. Sansone

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Several doses of tifluadom, an opioid benzodiazepine with affinity for opioid κ receptors, were tested on analgesia and locomotor activity in two strains of mice, the C57BL/6 and the DBA/2. The analgesic properties of the compound were confirmed in both strains by a tail flick test. As concerns locomotor activity both strains, that in previous researches showed opposite responses to opiates, were depressed by tifluadom, suggesting the involvement of κ receptors in this effect.

Original language	English
Pages (from-to)	318-323
Number of pages	6
Journal	Archives Internationales de Pharmacodynamie et de Therapie
Volume	270
Issue number	2
Publication status	Published - 1984

ASJC Scopus subject areas

Pharmacology

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abstract = "Several doses of tifluadom, an opioid benzodiazepine with affinity for opioid κ receptors, were tested on analgesia and locomotor activity in two strains of mice, the C57BL/6 and the DBA/2. The analgesic properties of the compound were confirmed in both strains by a tail flick test. As concerns locomotor activity both strains, that in previous researches showed opposite responses to opiates, were depressed by tifluadom, suggesting the involvement of κ receptors in this effect.",

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Locomotor depression by the opioid benzodiazepine tifluadom in mice

Abstract

ASJC Scopus subject areas

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