Locomotor depression by the opioid benzodiazepine tifluadom in mice

C. Castellano, F. Pavone, M. Sansone

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Several doses of tifluadom, an opioid benzodiazepine with affinity for opioid κ receptors, were tested on analgesia and locomotor activity in two strains of mice, the C57BL/6 and the DBA/2. The analgesic properties of the compound were confirmed in both strains by a tail flick test. As concerns locomotor activity both strains, that in previous researches showed opposite responses to opiates, were depressed by tifluadom, suggesting the involvement of κ receptors in this effect.

Original languageEnglish
Pages (from-to)318-323
Number of pages6
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume270
Issue number2
Publication statusPublished - 1984

Fingerprint

Locomotion
Benzodiazepines
Opioid Analgesics
Opiate Alkaloids
Opioid Receptors
Inbred C57BL Mouse
Analgesia
Analgesics
Tail
Research
tifluadom

ASJC Scopus subject areas

  • Pharmacology

Cite this

Locomotor depression by the opioid benzodiazepine tifluadom in mice. / Castellano, C.; Pavone, F.; Sansone, M.

In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 270, No. 2, 1984, p. 318-323.

Research output: Contribution to journalArticle

Castellano, C. ; Pavone, F. ; Sansone, M. / Locomotor depression by the opioid benzodiazepine tifluadom in mice. In: Archives Internationales de Pharmacodynamie et de Therapie. 1984 ; Vol. 270, No. 2. pp. 318-323.
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