Abstract
Several doses of tifluadom, an opioid benzodiazepine with affinity for opioid κ receptors, were tested on analgesia and locomotor activity in two strains of mice, the C57BL/6 and the DBA/2. The analgesic properties of the compound were confirmed in both strains by a tail flick test. As concerns locomotor activity both strains, that in previous researches showed opposite responses to opiates, were depressed by tifluadom, suggesting the involvement of κ receptors in this effect.
| Original language | English |
|---|---|
| Pages (from-to) | 318-323 |
| Number of pages | 6 |
| Journal | Archives Internationales de Pharmacodynamie et de Therapie |
| Volume | 270 |
| Issue number | 2 |
| Publication status | Published - 1984 |
ASJC Scopus subject areas
- Pharmacology
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Castellano, C., Pavone, F., & Sansone, M. (1984). Locomotor depression by the opioid benzodiazepine tifluadom in mice. Archives Internationales de Pharmacodynamie et de Therapie, 270(2), 318-323.