Abstract
Several doses of tifluadom, an opioid benzodiazepine with affinity for opioid κ receptors, were tested on analgesia and locomotor activity in two strains of mice, the C57BL/6 and the DBA/2. The analgesic properties of the compound were confirmed in both strains by a tail flick test. As concerns locomotor activity both strains, that in previous researches showed opposite responses to opiates, were depressed by tifluadom, suggesting the involvement of κ receptors in this effect.
| Original language | English |
|---|---|
| Pages (from-to) | 318-323 |
| Number of pages | 6 |
| Journal | Archives Internationales de Pharmacodynamie et de Therapie |
| Volume | 270 |
| Issue number | 2 |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Locomotor depression by the opioid benzodiazepine tifluadom in mice. / Castellano, C.; Pavone, F.; Sansone, M.
In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 270, No. 2, 1984, p. 318-323.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Locomotor depression by the opioid benzodiazepine tifluadom in mice
AU - Castellano, C.
AU - Pavone, F.
AU - Sansone, M.
PY - 1984
Y1 - 1984
N2 - Several doses of tifluadom, an opioid benzodiazepine with affinity for opioid κ receptors, were tested on analgesia and locomotor activity in two strains of mice, the C57BL/6 and the DBA/2. The analgesic properties of the compound were confirmed in both strains by a tail flick test. As concerns locomotor activity both strains, that in previous researches showed opposite responses to opiates, were depressed by tifluadom, suggesting the involvement of κ receptors in this effect.
AB - Several doses of tifluadom, an opioid benzodiazepine with affinity for opioid κ receptors, were tested on analgesia and locomotor activity in two strains of mice, the C57BL/6 and the DBA/2. The analgesic properties of the compound were confirmed in both strains by a tail flick test. As concerns locomotor activity both strains, that in previous researches showed opposite responses to opiates, were depressed by tifluadom, suggesting the involvement of κ receptors in this effect.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021139137&partnerID=8YFLogxK
M3 - Article
VL - 270
SP - 318
EP - 323
JO - Archives Internationales de Pharmacodynamie et de Therapie
JF - Archives Internationales de Pharmacodynamie et de Therapie
SN - 0003-9780
IS - 2
ER -