Abstract
Several doses of tifluadom, an opioid benzodiazepine with affinity for opioid κ receptors, were tested on analgesia and locomotor activity in two strains of mice, the C57BL/6 and the DBA/2. The analgesic properties of the compound were confirmed in both strains by a tail flick test. As concerns locomotor activity both strains, that in previous researches showed opposite responses to opiates, were depressed by tifluadom, suggesting the involvement of κ receptors in this effect.
Original language | English |
---|---|
Pages (from-to) | 318-323 |
Number of pages | 6 |
Journal | Archives Internationales de Pharmacodynamie et de Therapie |
Volume | 270 |
Issue number | 2 |
Publication status | Published - 1984 |
ASJC Scopus subject areas
- Pharmacology