Abstract
We report our experience in local fibrinolytic treatment (urokinase) of ilio-femoral thrombosis during the non-acute phase (dating not less than six days), and complicated with recurrent severe pulmonary embolism. The loading dosage was 1500 U/kg and the maintenance dosage 1500 U/kg/h. The thrombolysis was complete in one case and over 50% in three cases. The dyspnea and venous stasis clinical signs promptly improved with normalization of blood-gas measurements. By contrast, lung scannings did not detect any significant pulmonary perfusion variations. Neither important side effects nor recurrent pulmonary embolisms were seen, as well as deep venous re-thrombosis. In conclusion, local fibrinolytic treatment of deep venous thrombosis complicated with recurrent pulmonary embolisms can be suggested as a potentially effective and safe treatment. It may be valid even in late cases, where heaprin was ineffective.
| Original language | Italian |
|---|---|
| Pages (from-to) | 73-76 |
| Number of pages | 4 |
| Journal | Chirurgia |
| Volume | 6 |
| Issue number | 1-2 |
| Publication status | Published - 1993 |
Fingerprint
ASJC Scopus subject areas
- Surgery
Cite this
TRATTAMENTO FIBRINOLITICO LOCO-REGIONALE DELLA TROMBOSI VENOSA PROFONDA IN FASE NON ACUTA, COMPLICATA DA EMBOLIA POLMONARE RECIDIVANTE. / Ratto, G. B.; Fantino, G.; Tassara, E.; Moretti, A.; Bondi, S.
In: Chirurgia, Vol. 6, No. 1-2, 1993, p. 73-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - TRATTAMENTO FIBRINOLITICO LOCO-REGIONALE DELLA TROMBOSI VENOSA PROFONDA IN FASE NON ACUTA, COMPLICATA DA EMBOLIA POLMONARE RECIDIVANTE
AU - Ratto, G. B.
AU - Fantino, G.
AU - Tassara, E.
AU - Moretti, A.
AU - Bondi, S.
PY - 1993
Y1 - 1993
N2 - We report our experience in local fibrinolytic treatment (urokinase) of ilio-femoral thrombosis during the non-acute phase (dating not less than six days), and complicated with recurrent severe pulmonary embolism. The loading dosage was 1500 U/kg and the maintenance dosage 1500 U/kg/h. The thrombolysis was complete in one case and over 50% in three cases. The dyspnea and venous stasis clinical signs promptly improved with normalization of blood-gas measurements. By contrast, lung scannings did not detect any significant pulmonary perfusion variations. Neither important side effects nor recurrent pulmonary embolisms were seen, as well as deep venous re-thrombosis. In conclusion, local fibrinolytic treatment of deep venous thrombosis complicated with recurrent pulmonary embolisms can be suggested as a potentially effective and safe treatment. It may be valid even in late cases, where heaprin was ineffective.
AB - We report our experience in local fibrinolytic treatment (urokinase) of ilio-femoral thrombosis during the non-acute phase (dating not less than six days), and complicated with recurrent severe pulmonary embolism. The loading dosage was 1500 U/kg and the maintenance dosage 1500 U/kg/h. The thrombolysis was complete in one case and over 50% in three cases. The dyspnea and venous stasis clinical signs promptly improved with normalization of blood-gas measurements. By contrast, lung scannings did not detect any significant pulmonary perfusion variations. Neither important side effects nor recurrent pulmonary embolisms were seen, as well as deep venous re-thrombosis. In conclusion, local fibrinolytic treatment of deep venous thrombosis complicated with recurrent pulmonary embolisms can be suggested as a potentially effective and safe treatment. It may be valid even in late cases, where heaprin was ineffective.
KW - fibrinolysis
KW - pulmonary embolism
KW - thrombophlebitis
KW - urokinase
UR - http://www.scopus.com/inward/record.url?scp=0027318635&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027318635&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:0027318635
VL - 6
SP - 73
EP - 76
JO - Chirurgia (Turin)
JF - Chirurgia (Turin)
SN - 0394-9508
IS - 1-2
ER -