Locoregional IL-2 therapy in the treatment of colon cancer. Cell-induced lesions of a murine model

A. Caporale, A. Brescia, G. Galati, M. Castelli, S. Saputo, I. Terrenato, A. Cucina, A. Liverani, M. Gasparrini, A. Ciardi, M. Scarpini, Umile Michele Cosenza

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Local therapy with IL-2 may be very effective in the treatment of different forms of cancer. The aim of this study was to determine the effectiveness of IL-2 locoregional application in the treatment of colon cancer. Materials and Methods: Twenty eight syngenic BDIX rats were utilized in this study. The rats were divided into two groups of fourteen animals: group T (treatment) and group C (control). All rats of both groups were injected, under the splenic capsule, with T 107 DHD/K12/ TRb neoplastic cells. Then, within and around the site of the previous inoculation, the T group was injected with 1 ml of glucosate solutions + 0.1% albumin (BSA) containing 2.5×106 IU of IL-2 (Proleukin-Chiron), whereas the C group was injected with 1 ml of BSA alone. After three weeks, rats were sacrificed and the liver and spleen were removed. The following parameters were considered: volume and weight, neoplastic-non neoplastic tissue index of the spleen, mitotic index and vascular density of splenic and hepatic lesions. Results: All the studied parameters showed statistically significant differences in treated and untreated animals. Conclusion: This study of a murine model demonstrated that IL-2 locoregional therapy may be effective in the treatment of colon cancer.

Original languageEnglish
Pages (from-to)985-989
Number of pages5
JournalAnticancer Research
Volume27
Issue number2
Publication statusPublished - Mar 2007

Fingerprint

Colonic Neoplasms
Interleukin-2
Spleen
Mitotic Index
Liver
Therapeutics
Capsules
Blood Vessels
Albumins
Weights and Measures
Control Groups
Neoplasms

Keywords

  • Colon cancer
  • IL-2
  • Locoregional immunotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Caporale, A., Brescia, A., Galati, G., Castelli, M., Saputo, S., Terrenato, I., ... Cosenza, U. M. (2007). Locoregional IL-2 therapy in the treatment of colon cancer. Cell-induced lesions of a murine model. Anticancer Research, 27(2), 985-989.

Locoregional IL-2 therapy in the treatment of colon cancer. Cell-induced lesions of a murine model. / Caporale, A.; Brescia, A.; Galati, G.; Castelli, M.; Saputo, S.; Terrenato, I.; Cucina, A.; Liverani, A.; Gasparrini, M.; Ciardi, A.; Scarpini, M.; Cosenza, Umile Michele.

In: Anticancer Research, Vol. 27, No. 2, 03.2007, p. 985-989.

Research output: Contribution to journalArticle

Caporale, A, Brescia, A, Galati, G, Castelli, M, Saputo, S, Terrenato, I, Cucina, A, Liverani, A, Gasparrini, M, Ciardi, A, Scarpini, M & Cosenza, UM 2007, 'Locoregional IL-2 therapy in the treatment of colon cancer. Cell-induced lesions of a murine model', Anticancer Research, vol. 27, no. 2, pp. 985-989.
Caporale A, Brescia A, Galati G, Castelli M, Saputo S, Terrenato I et al. Locoregional IL-2 therapy in the treatment of colon cancer. Cell-induced lesions of a murine model. Anticancer Research. 2007 Mar;27(2):985-989.
Caporale, A. ; Brescia, A. ; Galati, G. ; Castelli, M. ; Saputo, S. ; Terrenato, I. ; Cucina, A. ; Liverani, A. ; Gasparrini, M. ; Ciardi, A. ; Scarpini, M. ; Cosenza, Umile Michele. / Locoregional IL-2 therapy in the treatment of colon cancer. Cell-induced lesions of a murine model. In: Anticancer Research. 2007 ; Vol. 27, No. 2. pp. 985-989.
@article{a16cc0f8dabc42c7aaea956815724119,
title = "Locoregional IL-2 therapy in the treatment of colon cancer. Cell-induced lesions of a murine model",
abstract = "Background: Local therapy with IL-2 may be very effective in the treatment of different forms of cancer. The aim of this study was to determine the effectiveness of IL-2 locoregional application in the treatment of colon cancer. Materials and Methods: Twenty eight syngenic BDIX rats were utilized in this study. The rats were divided into two groups of fourteen animals: group T (treatment) and group C (control). All rats of both groups were injected, under the splenic capsule, with T 107 DHD/K12/ TRb neoplastic cells. Then, within and around the site of the previous inoculation, the T group was injected with 1 ml of glucosate solutions + 0.1{\%} albumin (BSA) containing 2.5×106 IU of IL-2 (Proleukin-Chiron), whereas the C group was injected with 1 ml of BSA alone. After three weeks, rats were sacrificed and the liver and spleen were removed. The following parameters were considered: volume and weight, neoplastic-non neoplastic tissue index of the spleen, mitotic index and vascular density of splenic and hepatic lesions. Results: All the studied parameters showed statistically significant differences in treated and untreated animals. Conclusion: This study of a murine model demonstrated that IL-2 locoregional therapy may be effective in the treatment of colon cancer.",
keywords = "Colon cancer, IL-2, Locoregional immunotherapy",
author = "A. Caporale and A. Brescia and G. Galati and M. Castelli and S. Saputo and I. Terrenato and A. Cucina and A. Liverani and M. Gasparrini and A. Ciardi and M. Scarpini and Cosenza, {Umile Michele}",
year = "2007",
month = "3",
language = "English",
volume = "27",
pages = "985--989",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "2",

}

TY - JOUR

T1 - Locoregional IL-2 therapy in the treatment of colon cancer. Cell-induced lesions of a murine model

AU - Caporale, A.

AU - Brescia, A.

AU - Galati, G.

AU - Castelli, M.

AU - Saputo, S.

AU - Terrenato, I.

AU - Cucina, A.

AU - Liverani, A.

AU - Gasparrini, M.

AU - Ciardi, A.

AU - Scarpini, M.

AU - Cosenza, Umile Michele

PY - 2007/3

Y1 - 2007/3

N2 - Background: Local therapy with IL-2 may be very effective in the treatment of different forms of cancer. The aim of this study was to determine the effectiveness of IL-2 locoregional application in the treatment of colon cancer. Materials and Methods: Twenty eight syngenic BDIX rats were utilized in this study. The rats were divided into two groups of fourteen animals: group T (treatment) and group C (control). All rats of both groups were injected, under the splenic capsule, with T 107 DHD/K12/ TRb neoplastic cells. Then, within and around the site of the previous inoculation, the T group was injected with 1 ml of glucosate solutions + 0.1% albumin (BSA) containing 2.5×106 IU of IL-2 (Proleukin-Chiron), whereas the C group was injected with 1 ml of BSA alone. After three weeks, rats were sacrificed and the liver and spleen were removed. The following parameters were considered: volume and weight, neoplastic-non neoplastic tissue index of the spleen, mitotic index and vascular density of splenic and hepatic lesions. Results: All the studied parameters showed statistically significant differences in treated and untreated animals. Conclusion: This study of a murine model demonstrated that IL-2 locoregional therapy may be effective in the treatment of colon cancer.

AB - Background: Local therapy with IL-2 may be very effective in the treatment of different forms of cancer. The aim of this study was to determine the effectiveness of IL-2 locoregional application in the treatment of colon cancer. Materials and Methods: Twenty eight syngenic BDIX rats were utilized in this study. The rats were divided into two groups of fourteen animals: group T (treatment) and group C (control). All rats of both groups were injected, under the splenic capsule, with T 107 DHD/K12/ TRb neoplastic cells. Then, within and around the site of the previous inoculation, the T group was injected with 1 ml of glucosate solutions + 0.1% albumin (BSA) containing 2.5×106 IU of IL-2 (Proleukin-Chiron), whereas the C group was injected with 1 ml of BSA alone. After three weeks, rats were sacrificed and the liver and spleen were removed. The following parameters were considered: volume and weight, neoplastic-non neoplastic tissue index of the spleen, mitotic index and vascular density of splenic and hepatic lesions. Results: All the studied parameters showed statistically significant differences in treated and untreated animals. Conclusion: This study of a murine model demonstrated that IL-2 locoregional therapy may be effective in the treatment of colon cancer.

KW - Colon cancer

KW - IL-2

KW - Locoregional immunotherapy

UR - http://www.scopus.com/inward/record.url?scp=34247162394&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247162394&partnerID=8YFLogxK

M3 - Article

C2 - 17465231

AN - SCOPUS:34247162394

VL - 27

SP - 985

EP - 989

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 2

ER -