Locoregional IL-2 therapy in the treatment of colon cancer. Cell-induced lesions of a murine model

A. Caporale, A. Brescia, G. Galati, M. Castelli, S. Saputo, I. Terrenato, A. Cucina, A. Liverani, M. Gasparrini, A. Ciardi, M. Scarpini, Umile Michele Cosenza

Research output: Contribution to journalArticle

Abstract

Background: Local therapy with IL-2 may be very effective in the treatment of different forms of cancer. The aim of this study was to determine the effectiveness of IL-2 locoregional application in the treatment of colon cancer. Materials and Methods: Twenty eight syngenic BDIX rats were utilized in this study. The rats were divided into two groups of fourteen animals: group T (treatment) and group C (control). All rats of both groups were injected, under the splenic capsule, with T 107 DHD/K12/ TRb neoplastic cells. Then, within and around the site of the previous inoculation, the T group was injected with 1 ml of glucosate solutions + 0.1% albumin (BSA) containing 2.5×106 IU of IL-2 (Proleukin-Chiron), whereas the C group was injected with 1 ml of BSA alone. After three weeks, rats were sacrificed and the liver and spleen were removed. The following parameters were considered: volume and weight, neoplastic-non neoplastic tissue index of the spleen, mitotic index and vascular density of splenic and hepatic lesions. Results: All the studied parameters showed statistically significant differences in treated and untreated animals. Conclusion: This study of a murine model demonstrated that IL-2 locoregional therapy may be effective in the treatment of colon cancer.

Original languageEnglish
Pages (from-to)985-989
Number of pages5
JournalAnticancer Research
Volume27
Issue number2
Publication statusPublished - Mar 2007

Keywords

  • Colon cancer
  • IL-2
  • Locoregional immunotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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