Log odds of positive lymph nodes in colon cancer: A meaningful ratio-based lymph node classification system

Roberto Persiani, Ferdinando C M Cananzi, Alberto Biondi, Giuseppe Paliani, Andrea Tufo, Francesco Ferrara, Vincenzo Vigorita, Domenico D'Ugo

Research output: Contribution to journalArticle

Abstract

Background: The log odds of positive lymph nodes (LODDS), defined as the log of the ratio between the numbers of positive and negative lymph nodes, has recently been proposed as a new prognostic index in surgical oncology. The aim of the present study was to investigate whether the LODDS system of lymph node classification was a more accurate prognostic tool than the tumor node metastasis (TNM) and lymph node ratio (LNR) classifications in colon cancer patients. Materials and methods: Clinicopathologic data from 258 colon cancer patients who had undergone surgical resection were reviewed. Lymph node parameters were categorized according to the Internation Union Against Cancer/American Joint Cancer Commission (UICC/AJCC) TNM staging system, the LNR (LNR0 with ratio ≤ 0.05, LNR1 with 0.05 <ratio ≤ 0.20, LNR2 with ratio > 0.20), and the log odds ratio (LODDS0 ≤ -1.36, -1.36 <LODDS1 ≤ -0.53, and LODDS2 > -0.53). Results: The LODDS was able to identify patients who would have been included in different prognostic categories, according to both the TNM and LNR. In addition, LODDS was significantly related to the number of positive and negative lymph nodes, as well as the number of examined lymph nodes. In multivariate analysis, LODDS classification (LODDS0: HR 1; LODDS1: HR 3.687, p = 0.003; LODDS2: HR 9.440, p <0.001) was identified as an independent prognostic factor. Discussion: The LODDS system is a highly reliable staging system with strong predictive ability for patient outcome. Compared with other nodal staging systems, the prognostic power of LODDS is less influenced by the number of lymph nodes dissected and examined.

Original languageEnglish
Pages (from-to)667-674
Number of pages8
JournalWorld Journal of Surgery
Volume36
Issue number3
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Colonic Neoplasms
Lymph Nodes
Neoplasms
Neoplasm Metastasis
Multivariate Analysis
Joints
Odds Ratio

ASJC Scopus subject areas

  • Surgery

Cite this

Log odds of positive lymph nodes in colon cancer : A meaningful ratio-based lymph node classification system. / Persiani, Roberto; Cananzi, Ferdinando C M; Biondi, Alberto; Paliani, Giuseppe; Tufo, Andrea; Ferrara, Francesco; Vigorita, Vincenzo; D'Ugo, Domenico.

In: World Journal of Surgery, Vol. 36, No. 3, 03.2012, p. 667-674.

Research output: Contribution to journalArticle

Persiani, Roberto ; Cananzi, Ferdinando C M ; Biondi, Alberto ; Paliani, Giuseppe ; Tufo, Andrea ; Ferrara, Francesco ; Vigorita, Vincenzo ; D'Ugo, Domenico. / Log odds of positive lymph nodes in colon cancer : A meaningful ratio-based lymph node classification system. In: World Journal of Surgery. 2012 ; Vol. 36, No. 3. pp. 667-674.
@article{328fcce5baa647f08a1266f499b6093b,
title = "Log odds of positive lymph nodes in colon cancer: A meaningful ratio-based lymph node classification system",
abstract = "Background: The log odds of positive lymph nodes (LODDS), defined as the log of the ratio between the numbers of positive and negative lymph nodes, has recently been proposed as a new prognostic index in surgical oncology. The aim of the present study was to investigate whether the LODDS system of lymph node classification was a more accurate prognostic tool than the tumor node metastasis (TNM) and lymph node ratio (LNR) classifications in colon cancer patients. Materials and methods: Clinicopathologic data from 258 colon cancer patients who had undergone surgical resection were reviewed. Lymph node parameters were categorized according to the Internation Union Against Cancer/American Joint Cancer Commission (UICC/AJCC) TNM staging system, the LNR (LNR0 with ratio ≤ 0.05, LNR1 with 0.05 0.20), and the log odds ratio (LODDS0 ≤ -1.36, -1.36 <LODDS1 ≤ -0.53, and LODDS2 > -0.53). Results: The LODDS was able to identify patients who would have been included in different prognostic categories, according to both the TNM and LNR. In addition, LODDS was significantly related to the number of positive and negative lymph nodes, as well as the number of examined lymph nodes. In multivariate analysis, LODDS classification (LODDS0: HR 1; LODDS1: HR 3.687, p = 0.003; LODDS2: HR 9.440, p <0.001) was identified as an independent prognostic factor. Discussion: The LODDS system is a highly reliable staging system with strong predictive ability for patient outcome. Compared with other nodal staging systems, the prognostic power of LODDS is less influenced by the number of lymph nodes dissected and examined.",
author = "Roberto Persiani and Cananzi, {Ferdinando C M} and Alberto Biondi and Giuseppe Paliani and Andrea Tufo and Francesco Ferrara and Vincenzo Vigorita and Domenico D'Ugo",
year = "2012",
month = "3",
doi = "10.1007/s00268-011-1415-x",
language = "English",
volume = "36",
pages = "667--674",
journal = "World Journal of Surgery",
issn = "0364-2313",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Log odds of positive lymph nodes in colon cancer

T2 - A meaningful ratio-based lymph node classification system

AU - Persiani, Roberto

AU - Cananzi, Ferdinando C M

AU - Biondi, Alberto

AU - Paliani, Giuseppe

AU - Tufo, Andrea

AU - Ferrara, Francesco

AU - Vigorita, Vincenzo

AU - D'Ugo, Domenico

PY - 2012/3

Y1 - 2012/3

N2 - Background: The log odds of positive lymph nodes (LODDS), defined as the log of the ratio between the numbers of positive and negative lymph nodes, has recently been proposed as a new prognostic index in surgical oncology. The aim of the present study was to investigate whether the LODDS system of lymph node classification was a more accurate prognostic tool than the tumor node metastasis (TNM) and lymph node ratio (LNR) classifications in colon cancer patients. Materials and methods: Clinicopathologic data from 258 colon cancer patients who had undergone surgical resection were reviewed. Lymph node parameters were categorized according to the Internation Union Against Cancer/American Joint Cancer Commission (UICC/AJCC) TNM staging system, the LNR (LNR0 with ratio ≤ 0.05, LNR1 with 0.05 0.20), and the log odds ratio (LODDS0 ≤ -1.36, -1.36 <LODDS1 ≤ -0.53, and LODDS2 > -0.53). Results: The LODDS was able to identify patients who would have been included in different prognostic categories, according to both the TNM and LNR. In addition, LODDS was significantly related to the number of positive and negative lymph nodes, as well as the number of examined lymph nodes. In multivariate analysis, LODDS classification (LODDS0: HR 1; LODDS1: HR 3.687, p = 0.003; LODDS2: HR 9.440, p <0.001) was identified as an independent prognostic factor. Discussion: The LODDS system is a highly reliable staging system with strong predictive ability for patient outcome. Compared with other nodal staging systems, the prognostic power of LODDS is less influenced by the number of lymph nodes dissected and examined.

AB - Background: The log odds of positive lymph nodes (LODDS), defined as the log of the ratio between the numbers of positive and negative lymph nodes, has recently been proposed as a new prognostic index in surgical oncology. The aim of the present study was to investigate whether the LODDS system of lymph node classification was a more accurate prognostic tool than the tumor node metastasis (TNM) and lymph node ratio (LNR) classifications in colon cancer patients. Materials and methods: Clinicopathologic data from 258 colon cancer patients who had undergone surgical resection were reviewed. Lymph node parameters were categorized according to the Internation Union Against Cancer/American Joint Cancer Commission (UICC/AJCC) TNM staging system, the LNR (LNR0 with ratio ≤ 0.05, LNR1 with 0.05 0.20), and the log odds ratio (LODDS0 ≤ -1.36, -1.36 <LODDS1 ≤ -0.53, and LODDS2 > -0.53). Results: The LODDS was able to identify patients who would have been included in different prognostic categories, according to both the TNM and LNR. In addition, LODDS was significantly related to the number of positive and negative lymph nodes, as well as the number of examined lymph nodes. In multivariate analysis, LODDS classification (LODDS0: HR 1; LODDS1: HR 3.687, p = 0.003; LODDS2: HR 9.440, p <0.001) was identified as an independent prognostic factor. Discussion: The LODDS system is a highly reliable staging system with strong predictive ability for patient outcome. Compared with other nodal staging systems, the prognostic power of LODDS is less influenced by the number of lymph nodes dissected and examined.

UR - http://www.scopus.com/inward/record.url?scp=84857561288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857561288&partnerID=8YFLogxK

U2 - 10.1007/s00268-011-1415-x

DO - 10.1007/s00268-011-1415-x

M3 - Article

C2 - 22270984

AN - SCOPUS:84857561288

VL - 36

SP - 667

EP - 674

JO - World Journal of Surgery

JF - World Journal of Surgery

SN - 0364-2313

IS - 3

ER -