Abstract
Introduction: The objective of this study was to assess the effectiveness and potential benefits of the use of long-acting recombinant follicle-stimulating hormone (FSH) in a random-start protocol for fertility preservation in women with cancer. Material and methods: This is a retrospective before-and-after study performed between February 2013 and December 2015 in women who underwent ovarian hyperstimulation for oocyte cryobanking using a random-start approach. In the first part of the study period, the women were treated with daily recombinant FSH whereas in the second part the stimulation was initiated with long-acting recombinant FSH. The primary aim of the study was to compare the number of oocytes stored in the two study periods. In all, 140 women were ultimately selected. Results: Compared with daily recombinant FSH, the use of the long-acting compound was associated with a reduced number of injections (12.5 ± 3.5 vs. 16.4 ± 0.3; p < 0.001) and a longer duration of stimulation (11.4 ± 1.9 vs. 10.6 ± 1.9, p = 0.01). Conversely, the number of oocytes collected (13.7 ± 9.5 vs. 11.3 ± 7.0, p = 0.10) as well as those cryopreserved (11.0 ± 8.0 vs. 9.5 ± 5.8, p = 0.21) did not differ. Conclusions: The use of long-acting recombinant FSH in random-start protocols for fertility preservation appears to be a valuable option.
| Original language | English |
|---|---|
| Pages (from-to) | 949-953 |
| Number of pages | 5 |
| Journal | Acta Obstetricia et Gynecologica Scandinavica |
| Volume | 96 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 1 2017 |
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Keywords
- Cancer
- fertility preservation
- long-acting recombinant follicle-stimulating hormone
- oocytes
- random-start protocol
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Long-acting recombinant follicle-stimulating hormone in random-start ovarian stimulation protocols for fertility preservation in women with cancer. / Sarais, Veronica; Paffoni, Alessio; Pagliardini, Luca; Filippi, Francesca; Martinelli, Fabio; Mangili, Giorgia; Candiani, Massimo; Papaleo, Enrico.
In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 96, No. 8, 01.08.2017, p. 949-953.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-acting recombinant follicle-stimulating hormone in random-start ovarian stimulation protocols for fertility preservation in women with cancer
AU - Sarais, Veronica
AU - Paffoni, Alessio
AU - Pagliardini, Luca
AU - Filippi, Francesca
AU - Martinelli, Fabio
AU - Mangili, Giorgia
AU - Candiani, Massimo
AU - Papaleo, Enrico
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Introduction: The objective of this study was to assess the effectiveness and potential benefits of the use of long-acting recombinant follicle-stimulating hormone (FSH) in a random-start protocol for fertility preservation in women with cancer. Material and methods: This is a retrospective before-and-after study performed between February 2013 and December 2015 in women who underwent ovarian hyperstimulation for oocyte cryobanking using a random-start approach. In the first part of the study period, the women were treated with daily recombinant FSH whereas in the second part the stimulation was initiated with long-acting recombinant FSH. The primary aim of the study was to compare the number of oocytes stored in the two study periods. In all, 140 women were ultimately selected. Results: Compared with daily recombinant FSH, the use of the long-acting compound was associated with a reduced number of injections (12.5 ± 3.5 vs. 16.4 ± 0.3; p < 0.001) and a longer duration of stimulation (11.4 ± 1.9 vs. 10.6 ± 1.9, p = 0.01). Conversely, the number of oocytes collected (13.7 ± 9.5 vs. 11.3 ± 7.0, p = 0.10) as well as those cryopreserved (11.0 ± 8.0 vs. 9.5 ± 5.8, p = 0.21) did not differ. Conclusions: The use of long-acting recombinant FSH in random-start protocols for fertility preservation appears to be a valuable option.
AB - Introduction: The objective of this study was to assess the effectiveness and potential benefits of the use of long-acting recombinant follicle-stimulating hormone (FSH) in a random-start protocol for fertility preservation in women with cancer. Material and methods: This is a retrospective before-and-after study performed between February 2013 and December 2015 in women who underwent ovarian hyperstimulation for oocyte cryobanking using a random-start approach. In the first part of the study period, the women were treated with daily recombinant FSH whereas in the second part the stimulation was initiated with long-acting recombinant FSH. The primary aim of the study was to compare the number of oocytes stored in the two study periods. In all, 140 women were ultimately selected. Results: Compared with daily recombinant FSH, the use of the long-acting compound was associated with a reduced number of injections (12.5 ± 3.5 vs. 16.4 ± 0.3; p < 0.001) and a longer duration of stimulation (11.4 ± 1.9 vs. 10.6 ± 1.9, p = 0.01). Conversely, the number of oocytes collected (13.7 ± 9.5 vs. 11.3 ± 7.0, p = 0.10) as well as those cryopreserved (11.0 ± 8.0 vs. 9.5 ± 5.8, p = 0.21) did not differ. Conclusions: The use of long-acting recombinant FSH in random-start protocols for fertility preservation appears to be a valuable option.
KW - Cancer
KW - fertility preservation
KW - long-acting recombinant follicle-stimulating hormone
KW - oocytes
KW - random-start protocol
UR - http://www.scopus.com/inward/record.url?scp=85019410687&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019410687&partnerID=8YFLogxK
U2 - 10.1111/aogs.13146
DO - 10.1111/aogs.13146
M3 - Article
AN - SCOPUS:85019410687
VL - 96
SP - 949
EP - 953
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 8
ER -