Abstract
INTRODUCTION: The objective of this study was to assess the effectiveness and potential benefits of the use of long-acting recombinant follicle-stimulating hormone (FSH) in a random-start protocol for fertility preservation in women with cancer.
MATERIAL AND METHODS: This is a retrospective before-and-after study performed between February 2013 and December 2015 in women who underwent ovarian hyperstimulation for oocyte cryobanking using a random-start approach. In the first part of the study period, the women were treated with daily recombinant FSH whereas in the second part the stimulation was initiated with long-acting recombinant FSH. The primary aim of the study was to compare the number of oocytes stored in the two study periods. In all, 140 women were ultimately selected.
RESULTS: Compared with daily recombinant FSH, the use of the long-acting compound was associated with a reduced number of injections (12.5 ± 3.5 vs. 16.4 ± 0.3; p < 0.001) and a longer duration of stimulation (11.4 ± 1.9 vs. 10.6 ± 1.9, p = 0.01). Conversely, the number of oocytes collected (13.7 ± 9.5 vs. 11.3 ± 7.0, p = 0.10) as well as those cryopreserved (11.0 ± 8.0 vs. 9.5 ± 5.8, p = 0.21) did not differ.
CONCLUSIONS: The use of long-acting recombinant FSH in random-start protocols for fertility preservation appears to be a valuable option.
| Original language | English |
|---|---|
| Pages (from-to) | 949-953 |
| Number of pages | 5 |
| Journal | Acta Obstetricia et Gynecologica Scandinavica |
| Volume | 96 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2017 |
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Keywords
- Breast Neoplasms
- Delayed-Action Preparations
- Drug Administration Schedule
- Female
- Fertility Preservation
- Follicle Stimulating Hormone
- Humans
- Ovarian Neoplasms
- Ovulation Induction
- Pregnancy
- Retrospective Studies
- Treatment Outcome
- Journal Article
Cite this
Long-acting recombinant follicle-stimulating hormone in random-start ovarian stimulation protocols for fertility preservation in women with cancer. / Sarais, Veronica; Paffoni, Alessio; Pagliardini, Luca; Filippi, Francesca; Martinelli, Fabio; Mangili, Giorgia; Candiani, Massimo; Papaleo, Enrico.
In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 96, No. 8, 08.2017, p. 949-953.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Long-acting recombinant follicle-stimulating hormone in random-start ovarian stimulation protocols for fertility preservation in women with cancer
AU - Sarais, Veronica
AU - Paffoni, Alessio
AU - Pagliardini, Luca
AU - Filippi, Francesca
AU - Martinelli, Fabio
AU - Mangili, Giorgia
AU - Candiani, Massimo
AU - Papaleo, Enrico
N1 - © 2017 Nordic Federation of Societies of Obstetrics and Gynecology.
PY - 2017/8
Y1 - 2017/8
N2 - INTRODUCTION: The objective of this study was to assess the effectiveness and potential benefits of the use of long-acting recombinant follicle-stimulating hormone (FSH) in a random-start protocol for fertility preservation in women with cancer.MATERIAL AND METHODS: This is a retrospective before-and-after study performed between February 2013 and December 2015 in women who underwent ovarian hyperstimulation for oocyte cryobanking using a random-start approach. In the first part of the study period, the women were treated with daily recombinant FSH whereas in the second part the stimulation was initiated with long-acting recombinant FSH. The primary aim of the study was to compare the number of oocytes stored in the two study periods. In all, 140 women were ultimately selected.RESULTS: Compared with daily recombinant FSH, the use of the long-acting compound was associated with a reduced number of injections (12.5 ± 3.5 vs. 16.4 ± 0.3; p < 0.001) and a longer duration of stimulation (11.4 ± 1.9 vs. 10.6 ± 1.9, p = 0.01). Conversely, the number of oocytes collected (13.7 ± 9.5 vs. 11.3 ± 7.0, p = 0.10) as well as those cryopreserved (11.0 ± 8.0 vs. 9.5 ± 5.8, p = 0.21) did not differ.CONCLUSIONS: The use of long-acting recombinant FSH in random-start protocols for fertility preservation appears to be a valuable option.
AB - INTRODUCTION: The objective of this study was to assess the effectiveness and potential benefits of the use of long-acting recombinant follicle-stimulating hormone (FSH) in a random-start protocol for fertility preservation in women with cancer.MATERIAL AND METHODS: This is a retrospective before-and-after study performed between February 2013 and December 2015 in women who underwent ovarian hyperstimulation for oocyte cryobanking using a random-start approach. In the first part of the study period, the women were treated with daily recombinant FSH whereas in the second part the stimulation was initiated with long-acting recombinant FSH. The primary aim of the study was to compare the number of oocytes stored in the two study periods. In all, 140 women were ultimately selected.RESULTS: Compared with daily recombinant FSH, the use of the long-acting compound was associated with a reduced number of injections (12.5 ± 3.5 vs. 16.4 ± 0.3; p < 0.001) and a longer duration of stimulation (11.4 ± 1.9 vs. 10.6 ± 1.9, p = 0.01). Conversely, the number of oocytes collected (13.7 ± 9.5 vs. 11.3 ± 7.0, p = 0.10) as well as those cryopreserved (11.0 ± 8.0 vs. 9.5 ± 5.8, p = 0.21) did not differ.CONCLUSIONS: The use of long-acting recombinant FSH in random-start protocols for fertility preservation appears to be a valuable option.
KW - Breast Neoplasms
KW - Delayed-Action Preparations
KW - Drug Administration Schedule
KW - Female
KW - Fertility Preservation
KW - Follicle Stimulating Hormone
KW - Humans
KW - Ovarian Neoplasms
KW - Ovulation Induction
KW - Pregnancy
KW - Retrospective Studies
KW - Treatment Outcome
KW - Journal Article
U2 - 10.1111/aogs.13146
DO - 10.1111/aogs.13146
M3 - Article
C2 - 28382680
VL - 96
SP - 949
EP - 953
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 8
ER -