Long-chain n-3 fatty acids in lipid rafts: Implications for anti-inflammatory effects

Research output: Contribution to journalArticlepeer-review

Abstract

Emerging evidence indicates that dietary intake of long-chain n-3 fatty acids changes the lipid composition of lipid rafts and caveolae, which are cholesterol- and sphingolipid-rich microdomains of the plasma membrane. Membrane proteins that are involved in signal transduction events relevant to inflammation are specifically localised to these microdomains. By altering the lipid composition of the membrane microdomains, n-3 fatty acids have the potential to modulate these signalling events and exert anti-inflammatory actions.

Original languageEnglish
JournalJournal of Cardiovascular Medicine
Volume8
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Caveolae
  • Lipid rafts
  • Membrane microdomains
  • n-3 fatty acids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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