Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child

Manola Comar, Pierlanfranco D'Agaro, Douglas Horejsh, Monica Galvan, Simona Fiorentini, Marino Andolina, Arnaldo Caruso, Dario Di Luca, Cesare Campello

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We report a long-lasting (8-month) reactivation of human herpesvirus 6 (HHV-6) infection in child who had undergone cord blood stem cell transplantation. The reactivation was characterized by high viral loads and by immediate-early mRNA positivity. HHV-6 infection was associated with a deep depletion of CD3, while the CD4/CD8 ratio remained substantially unchanged.

Original languageEnglish
Pages (from-to)2002-2003
Number of pages2
JournalJournal of Clinical Microbiology
Volume43
Issue number4
DOIs
Publication statusPublished - Apr 2005

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Cord Blood Stem Cell Transplantation
Human Herpesvirus 6
Herpesviridae Infections
T-Lymphocytes
CD4-CD8 Ratio
Viral Load
Messenger RNA

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child. / Comar, Manola; D'Agaro, Pierlanfranco; Horejsh, Douglas; Galvan, Monica; Fiorentini, Simona; Andolina, Marino; Caruso, Arnaldo; Di Luca, Dario; Campello, Cesare.

In: Journal of Clinical Microbiology, Vol. 43, No. 4, 04.2005, p. 2002-2003.

Research output: Contribution to journalArticle

Comar, M, D'Agaro, P, Horejsh, D, Galvan, M, Fiorentini, S, Andolina, M, Caruso, A, Di Luca, D & Campello, C 2005, 'Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child', Journal of Clinical Microbiology, vol. 43, no. 4, pp. 2002-2003. https://doi.org/10.1128/JCM.43.4.2002-2003.2005
Comar, Manola ; D'Agaro, Pierlanfranco ; Horejsh, Douglas ; Galvan, Monica ; Fiorentini, Simona ; Andolina, Marino ; Caruso, Arnaldo ; Di Luca, Dario ; Campello, Cesare. / Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child. In: Journal of Clinical Microbiology. 2005 ; Vol. 43, No. 4. pp. 2002-2003.
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