TY - JOUR
T1 - Long-lasting effect of cyclosporin-a on anemia associated with idiopathic myelofibrosis
AU - Pietrasanta, Daniela
AU - Clavio, Marino
AU - Vallebella, Emanuela
AU - Beltrami, Germana
AU - Cavaliere, Marina
AU - Gobbi, Marco
PY - 1997/7
Y1 - 1997/7
N2 - Some reports suggest that immunologic mechanisms may play a role in the pathogenesis of anemia in idiopathic myelofibrosis (IMF). Herein we report the case of a transfusion dependent IMF patient with psoriasis in whom cyclosporin-A (CyA) treatment for skin lesions (200 mg/day) was associated with long-lasting correction of anemia. After 2 months of CyA therapy the patient's Hb level increased and he became transfusion free in 4 months. After 12 months immunosuppressive therapy was discontinued due to renal toxicity, yet the Hb level remained stable for an additional 12 months. The patient is currently being administered CyA at a reduced dosage because of mild renal impairment along with transfusional support consisting of a median of 2 red cell units/month. Altogether the patient received no transfusional support for 36 months. This case, as well as other reports, suggests that the issue of immunosuppressive treatment in IMF anemia deserves further investigation.
AB - Some reports suggest that immunologic mechanisms may play a role in the pathogenesis of anemia in idiopathic myelofibrosis (IMF). Herein we report the case of a transfusion dependent IMF patient with psoriasis in whom cyclosporin-A (CyA) treatment for skin lesions (200 mg/day) was associated with long-lasting correction of anemia. After 2 months of CyA therapy the patient's Hb level increased and he became transfusion free in 4 months. After 12 months immunosuppressive therapy was discontinued due to renal toxicity, yet the Hb level remained stable for an additional 12 months. The patient is currently being administered CyA at a reduced dosage because of mild renal impairment along with transfusional support consisting of a median of 2 red cell units/month. Altogether the patient received no transfusional support for 36 months. This case, as well as other reports, suggests that the issue of immunosuppressive treatment in IMF anemia deserves further investigation.
KW - Anemia
KW - Cyclosporin A
KW - Idiopathic myelofibrosis
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M3 - Article
C2 - 9299862
AN - SCOPUS:0031468594
VL - 82
SP - 458
EP - 459
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 4
ER -