Long-lasting efficacy and safety of lenalidomide maintenance in patients with relapsed diffuse large B-cell lymphoma who are not eligible for or failed autologous transplantation: Hematological Oncology

A.J.M. Ferreri; M. Sassone; P. Angelillo; F. Zaja; A. Re; A. Di Rocco; M. Spina; A. Fabbri; C. Stelitano; M. Frezzato; S. Volpetti; R. Zambello; C. Rusconi; D. De Lorenzo; E. Scarano; A. Arcari; G. Bertoldero; A. Nonis; T. Calimeri; S. Perrone; C. Cecchetti; V. Tarantino; S. Steffanoni; M. Foppoli; F. Ciceri; M. Ponzoni

doi:10.1002/hon.2742

Long-lasting efficacy and safety of lenalidomide maintenance in patients with relapsed diffuse large B-cell lymphoma who are not eligible for or failed autologous transplantation: Hematological Oncology

A.J.M. Ferreri, M. Sassone, P. Angelillo, F. Zaja, A. Re, A. Di Rocco, M. Spina, A. Fabbri, C. Stelitano, M. Frezzato, S. Volpetti, R. Zambello, C. Rusconi, D. De Lorenzo, E. Scarano, A. Arcari, G. Bertoldero, A. Nonis, T. Calimeri, S. PerroneC. Cecchetti, V. Tarantino, S. Steffanoni, M. Foppoli, F. Ciceri, M. Ponzoni

Research output: Contribution to journal › Article › peer-review

Abstract

We report final results of a phase II trial addressing efficacy and feasibility of lenalidomide maintenance in patients with chemosensitive relapse of diffuse large B-cell lymphoma (DLBCL) not eligible for or failed after autologous stem cell transplantation (ASCT). Patients with relapsed DLBCL who achieved at least a partial response to salvage chemoimmunotherapy were enrolled and treated with lenalidomide 25 mg/day for 21 of 28 days for 2 years or until progression or unacceptable toxicity. Primary endpoint was 1-year PFS. Forty-six of 48 enrolled patients were assessable. Most patients had IPI ≥2, advanced stage and extranodal disease before the salvage treatment that led to trial registration; 28 (61%) patients were older than 70 years. Lenalidomide was well tolerated. With the exception of neutropenia, grade-4 toxicities occurred in

Original language	English
Pages (from-to)	257-265
Number of pages	9
Journal	Hematol. Oncol.
Volume	38
Issue number	3
DOIs	https://doi.org/10.1002/hon.2742
Publication status	Published - 2020

Keywords

cell of origin
diffuse large B-cell lymphoma
immunomodulators
lenalidomide
maintenance
transformed high-grade lymphoma
angiogenesis inhibitor
adult
aged
anemia
Article
autologous stem cell transplantation
cancer chemotherapy
cancer immunotherapy
cancer recurrence
clinical article
constipation
diarrhea
diffuse large B cell lymphoma
drug efficacy
drug safety
febrile neutropenia
female
follow up
human
liver toxicity
male
multicenter study
nausea and vomiting
nephrotoxicity
neurotoxicity
neutropenia
phase 2 clinical trial
priority journal
progression free survival
rash
salvage therapy
thrombocytopenia
thrombosis
treatment failure
treatment response
clinical trial
maintenance chemotherapy
middle aged
pathology
prognosis
survival rate
tumor recurrence
very elderly
Adult
Aged
Aged, 80 and over
Angiogenesis Inhibitors
Female
Follow-Up Studies
Humans
Lenalidomide
Lymphoma, Large B-Cell, Diffuse
Maintenance Chemotherapy
Male
Middle Aged
Neoplasm Recurrence, Local
Prognosis
Salvage Therapy
Survival Rate

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Ferreri, A. J. M., Sassone, M., Angelillo, P., Zaja, F., Re, A., Di Rocco, A., Spina, M., Fabbri, A., Stelitano, C., Frezzato, M., Volpetti, S., Zambello, R., Rusconi, C., De Lorenzo, D., Scarano, E., Arcari, A., Bertoldero, G., Nonis, A., Calimeri, T., ... Ponzoni, M. (2020). Long-lasting efficacy and safety of lenalidomide maintenance in patients with relapsed diffuse large B-cell lymphoma who are not eligible for or failed autologous transplantation: Hematological Oncology. Hematol. Oncol., 38(3), 257-265. https://doi.org/10.1002/hon.2742

Long-lasting efficacy and safety of lenalidomide maintenance in patients with relapsed diffuse large B-cell lymphoma who are not eligible for or failed autologous transplantation : Hematological Oncology. / Ferreri, A.J.M.; Sassone, M.; Angelillo, P.; Zaja, F.; Re, A.; Di Rocco, A.; Spina, M.; Fabbri, A.; Stelitano, C.; Frezzato, M.; Volpetti, S.; Zambello, R.; Rusconi, C.; De Lorenzo, D.; Scarano, E.; Arcari, A.; Bertoldero, G.; Nonis, A.; Calimeri, T.; Perrone, S.; Cecchetti, C.; Tarantino, V.; Steffanoni, S.; Foppoli, M.; Ciceri, F.; Ponzoni, M.

In: Hematol. Oncol., Vol. 38, No. 3, 2020, p. 257-265.

Research output: Contribution to journal › Article › peer-review

Ferreri, AJM , Sassone, M, Angelillo, P, Zaja, F, Re, A, Di Rocco, A, Spina, M, Fabbri, A, Stelitano, C, Frezzato, M, Volpetti, S, Zambello, R, Rusconi, C, De Lorenzo, D, Scarano, E, Arcari, A, Bertoldero, G, Nonis, A, Calimeri, T, Perrone, S, Cecchetti, C, Tarantino, V, Steffanoni, S , Foppoli, M , Ciceri, F & Ponzoni, M 2020, 'Long-lasting efficacy and safety of lenalidomide maintenance in patients with relapsed diffuse large B-cell lymphoma who are not eligible for or failed autologous transplantation: Hematological Oncology', Hematol. Oncol., vol. 38, no. 3, pp. 257-265. https://doi.org/10.1002/hon.2742

Ferreri, A.J.M. ; Sassone, M. ; Angelillo, P. ; Zaja, F. ; Re, A. ; Di Rocco, A. ; Spina, M. ; Fabbri, A. ; Stelitano, C. ; Frezzato, M. ; Volpetti, S. ; Zambello, R. ; Rusconi, C. ; De Lorenzo, D. ; Scarano, E. ; Arcari, A. ; Bertoldero, G. ; Nonis, A. ; Calimeri, T. ; Perrone, S. ; Cecchetti, C. ; Tarantino, V. ; Steffanoni, S. ; Foppoli, M. ; Ciceri, F. ; Ponzoni, M. / Long-lasting efficacy and safety of lenalidomide maintenance in patients with relapsed diffuse large B-cell lymphoma who are not eligible for or failed autologous transplantation : Hematological Oncology. In: Hematol. Oncol. 2020 ; Vol. 38, No. 3. pp. 257-265.

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abstract = "We report final results of a phase II trial addressing efficacy and feasibility of lenalidomide maintenance in patients with chemosensitive relapse of diffuse large B-cell lymphoma (DLBCL) not eligible for or failed after autologous stem cell transplantation (ASCT). Patients with relapsed DLBCL who achieved at least a partial response to salvage chemoimmunotherapy were enrolled and treated with lenalidomide 25 mg/day for 21 of 28 days for 2 years or until progression or unacceptable toxicity. Primary endpoint was 1-year PFS. Forty-six of 48 enrolled patients were assessable. Most patients had IPI ≥2, advanced stage and extranodal disease before the salvage treatment that led to trial registration; 28 (61%) patients were older than 70 years. Lenalidomide was well tolerated. With the exception of neutropenia, grade-4 toxicities occurred in ",

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author = "A.J.M. Ferreri and M. Sassone and P. Angelillo and F. Zaja and A. Re and {Di Rocco}, A. and M. Spina and A. Fabbri and C. Stelitano and M. Frezzato and S. Volpetti and R. Zambello and C. Rusconi and {De Lorenzo}, D. and E. Scarano and A. Arcari and G. Bertoldero and A. Nonis and T. Calimeri and S. Perrone and C. Cecchetti and V. Tarantino and S. Steffanoni and M. Foppoli and F. Ciceri and M. Ponzoni",

note = "Export Date: 11 March 2021 CODEN: HAOND Correspondence Address: Ferreri, A.J.M.; Lymphoma Unit, Italy; email: ferreri.andres@hsr.it Chemicals/CAS: lenalidomide, 191732-72-6; Angiogenesis Inhibitors; Lenalidomide Funding details: Celgene Funding text 1: This trial was partially supported by a grant provided by Celgene Corp. NJ, USA. Lenalidomide was kindly provided by Celgene Corp. NJ, USA. The authors are indebted to our patients and their families for their generous commitment. We also acknowledge hematologists, oncologists, pathologists, and data managers from the 12 participating centers for the sustained collaboration. Neither the sponsor (IRCCS San Raffaele Scientific Institute, Milano, Italy) nor the grant provider had any role in the design, data collection, analysis, results interpretation, and writing of the report.",

year = "2020",

doi = "10.1002/hon.2742",

language = "English",

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pages = "257--265",

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T1 - Long-lasting efficacy and safety of lenalidomide maintenance in patients with relapsed diffuse large B-cell lymphoma who are not eligible for or failed autologous transplantation

T2 - Hematological Oncology

AU - Ferreri, A.J.M.

AU - Sassone, M.

AU - Angelillo, P.

AU - Zaja, F.

AU - Re, A.

AU - Di Rocco, A.

AU - Spina, M.

AU - Fabbri, A.

AU - Stelitano, C.

AU - Frezzato, M.

AU - Volpetti, S.

AU - Zambello, R.

AU - Rusconi, C.

AU - De Lorenzo, D.

AU - Scarano, E.

AU - Arcari, A.

AU - Bertoldero, G.

AU - Nonis, A.

AU - Calimeri, T.

AU - Perrone, S.

AU - Cecchetti, C.

AU - Tarantino, V.

AU - Steffanoni, S.

AU - Foppoli, M.

AU - Ciceri, F.

AU - Ponzoni, M.

N1 - Export Date: 11 March 2021 CODEN: HAOND Correspondence Address: Ferreri, A.J.M.; Lymphoma Unit, Italy; email: ferreri.andres@hsr.it Chemicals/CAS: lenalidomide, 191732-72-6; Angiogenesis Inhibitors; Lenalidomide Funding details: Celgene Funding text 1: This trial was partially supported by a grant provided by Celgene Corp. NJ, USA. Lenalidomide was kindly provided by Celgene Corp. NJ, USA. The authors are indebted to our patients and their families for their generous commitment. We also acknowledge hematologists, oncologists, pathologists, and data managers from the 12 participating centers for the sustained collaboration. Neither the sponsor (IRCCS San Raffaele Scientific Institute, Milano, Italy) nor the grant provider had any role in the design, data collection, analysis, results interpretation, and writing of the report.

PY - 2020

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