Long-lasting improvement of myocardial perfusion and chronic refractory angina after autologous intramyocardial PBSC transplantation

Giulio Pompilio, A. Cannata, M. Pesce, M. C. Capogrossi, P. Biglioli

Research output: Contribution to journalArticle

Abstract

We report the case of a 60-year-old man with patent coronary by-pass grafts on the left anterior descending and circumflex coronary arteries, who experienced recurrent Canadian class IV angina refractory to medical and interventional treatments for a dominant right coronary artery occlusion. He underwent autologous PBSC transplant into the inferior ventricular wall through a minimally invasive approach as a stand-alone therapy, in an attempt to induce therapeutic angiogenesis. Six months after the operation, angina significantly ameliorated; scintigraphy and coronary angiography showed a marked improvement in perfusion of the target injection area. These benefits had persisted at 25 months after stem cell transplant.

Original languageEnglish
Pages (from-to)494-496
Number of pages3
JournalCytotherapy
Volume7
Issue number6
DOIs
Publication statusPublished - Dec 2005

Keywords

  • Angiogenesis
  • BM-derived stem cells
  • Coronary artery disease

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology

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