Long non-coding RNA-ribonucleoprotein networks in the post-transcriptional control of gene expression

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Abstract

Although mammals possess roughly the same number of protein-coding genes as worms, it is evident that the non-coding transcriptome content has become far broader and more sophisticated during evolution. Indeed, the vital regulatory importance of both short and long non-coding RNAs (lncRNAs) has been demonstrated during the last two decades. RNA binding proteins (RBPs) represent approximately 7.5% of all proteins and regulate the fate and function of a huge number of transcripts thus contributing to ensure cellular homeostasis. Transcriptomic and proteomic studies revealed that RBP-based complexes often include lncRNAs. This review will describe examples of how lncRNA-RBP networks can virtually control all the post-transcriptional events in the cell.

Original languageEnglish
Article number30040
JournalNon-coding RNA
Volume6
Issue number3
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Long non-coding RNA 1
  • Post-transcriptional regulation
  • RNA binding protein 2

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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