Long non-coding RNAs in B-cell malignancies: A comprehensive overview

Lucia Nobili, Domenica Ronchetti, Elisa Taiana, Antonino Neri

Research output: Contribution to journalReview article

Abstract

B-cell malignancies constitute a large part of hematological neoplasias. They represent a heterogeneous group of diseases, including Hodgkin's lymphoma, most non-Hodgkin's lymphomas (NHL), some leukemias and myelomas. B-cell malignancies reflect defined stages of normal B-cell differentiation and this represents the major basis for their classifification. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts longer than 200 nucleotides, for which many recent studies have demonstrated a function in regulating gene expression, cell biology and carcinogenesis. Deregulated expression levels of lncRNAs have been observed in various types of cancers including hematological malignancies. The involvement of lncRNAs in cancer initiation and progression and their attractive features both as biomarker and for therapeutic research are becoming increasingly evident. In this review, we summarize the recent literature to highlight the status of the knowledge of lncRNAs role in normal B-cell development and in the pathogenesis of B-cell tumors.

Original languageEnglish
Pages (from-to)60605-60623
Number of pages19
JournalOncotarget
Volume8
Issue number36
DOIs
Publication statusPublished - 2017

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Keywords

  • B-cell differentiation
  • B-cell malignancies
  • Expression profiling
  • Long non-coding RNAs
  • Transcription regulation

ASJC Scopus subject areas

  • Oncology

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