TY - JOUR
T1 - Long non-coding RNAs in B-cell malignancies
T2 - A comprehensive overview
AU - Nobili, Lucia
AU - Ronchetti, Domenica
AU - Taiana, Elisa
AU - Neri, Antonino
PY - 2017
Y1 - 2017
N2 - B-cell malignancies constitute a large part of hematological neoplasias. They represent a heterogeneous group of diseases, including Hodgkin's lymphoma, most non-Hodgkin's lymphomas (NHL), some leukemias and myelomas. B-cell malignancies reflect defined stages of normal B-cell differentiation and this represents the major basis for their classifification. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts longer than 200 nucleotides, for which many recent studies have demonstrated a function in regulating gene expression, cell biology and carcinogenesis. Deregulated expression levels of lncRNAs have been observed in various types of cancers including hematological malignancies. The involvement of lncRNAs in cancer initiation and progression and their attractive features both as biomarker and for therapeutic research are becoming increasingly evident. In this review, we summarize the recent literature to highlight the status of the knowledge of lncRNAs role in normal B-cell development and in the pathogenesis of B-cell tumors.
AB - B-cell malignancies constitute a large part of hematological neoplasias. They represent a heterogeneous group of diseases, including Hodgkin's lymphoma, most non-Hodgkin's lymphomas (NHL), some leukemias and myelomas. B-cell malignancies reflect defined stages of normal B-cell differentiation and this represents the major basis for their classifification. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts longer than 200 nucleotides, for which many recent studies have demonstrated a function in regulating gene expression, cell biology and carcinogenesis. Deregulated expression levels of lncRNAs have been observed in various types of cancers including hematological malignancies. The involvement of lncRNAs in cancer initiation and progression and their attractive features both as biomarker and for therapeutic research are becoming increasingly evident. In this review, we summarize the recent literature to highlight the status of the knowledge of lncRNAs role in normal B-cell development and in the pathogenesis of B-cell tumors.
KW - B-cell differentiation
KW - B-cell malignancies
KW - Expression profiling
KW - Long non-coding RNAs
KW - Transcription regulation
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U2 - 10.18632/oncotarget.17303
DO - 10.18632/oncotarget.17303
M3 - Review article
AN - SCOPUS:85030451024
VL - 8
SP - 60605
EP - 60623
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
IS - 36
ER -