Long non-coding RNAs in normal and malignant hematopoiesis

Lucia Nobili, Marta Lionetti, Antonino Neri

Research output: Contribution to journalReview articlepeer-review

Abstract

Long non coding RNAs (lncRNAs) are defined as ncRNAs of more than 200 nt in length. They are involved in a large spectrum of biological processes, such as maintenance of genome integrity, genomic imprinting, cell differentiation, and development by means of mechanisms that remain to be fully elucidated. Besides their role in normal cellular physiology, accumulating evidence has linked lncRNA expression and functions to cancer development and progression. In this review, we summarize and discuss what is known about their expression and roles in hematopoiesis with a particular focus on their cell-type specificity, functional interactions, and involvement in the pathobiology of hematological malignancies.

Original languageEnglish
Pages (from-to)50666-50681
Number of pages16
JournalOncotarget
Volume7
Issue number31
DOIs
Publication statusPublished - 2016

Keywords

  • Hematological malignancies
  • Hematopoiesis
  • Long noncoding RNAs
  • Transcriptional regulation
  • Translation regulation

ASJC Scopus subject areas

  • Oncology

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