Long Noncoding RNAs and Cardiac Disease

Simona Greco, Antonio Salgado Somoza, Yvan Devaux, Fabio Martelli

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Significance: To maintain homeostasis, gene expression has to be tightly regulated by complex and multiple mechanisms occurring at the epigenetic, transcriptional, and post-transcriptional levels. One crucial regulatory component is represented by long noncoding RNAs (lncRNAs), nonprotein-coding RNA species implicated in all of these levels. Thus, lncRNAs have been associated with any given process or pathway of interest in a variety of systems, including the heart. Recent Advances: Mounting evidence implicates lncRNAs in cardiovascular diseases (CVD) and progression and their presence in the blood of heart disease patients indicates that they are attractive potential biomarkers. Critical Issues: Our understanding of the regulation and molecular mechanisms of action of most lncRNAs remains rudimentary. A challenge is represented by their often low evolutionary sequence conservation that limits the use of animal models for preclinical studies. Nevertheless, a growing number of lncRNAs with an impact on heart function is rapidly accumulating. In this study, we will discuss (i) lncRNAs that control heart homeostasis and disease; (ii) concepts, approaches, and methodologies necessary to study lncRNAs in the heart; and (iii) challenges posed and opportunities presented by lncRNAs as potential therapeutic targets and biomarkers. Future Directions: A deeper knowledge of the molecular mechanisms underpinning CVDs is necessary to develop more effective treatments. Further studies are needed to clarify the regulation and function of lncRNAs in the heart before they can be considered as therapeutic targets and disease biomarkers.

Original languageEnglish
Pages (from-to)880-901
Number of pages22
JournalAntioxidants and Redox Signaling
Volume29
Issue number9
DOIs
Publication statusPublished - Sep 20 2018

Fingerprint

Long Noncoding RNA
Heart Diseases
Biomarkers
Homeostasis
Hematologic Diseases
Mountings
Epigenomics
Gene expression
Disease Progression
Chemical vapor deposition
Conservation
Animals
Blood
Cardiovascular Diseases
Therapeutics
Animal Models
RNA
Gene Expression

Keywords

  • biomarkers
  • gene expression
  • heart diseases
  • long noncoding RNAs

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Long Noncoding RNAs and Cardiac Disease. / Greco, Simona; Somoza, Antonio Salgado; Devaux, Yvan; Martelli, Fabio.

In: Antioxidants and Redox Signaling, Vol. 29, No. 9, 20.09.2018, p. 880-901.

Research output: Contribution to journalReview article

Greco, Simona ; Somoza, Antonio Salgado ; Devaux, Yvan ; Martelli, Fabio. / Long Noncoding RNAs and Cardiac Disease. In: Antioxidants and Redox Signaling. 2018 ; Vol. 29, No. 9. pp. 880-901.
@article{6c83aebb113b45ad8deef0b12e5058ee,
title = "Long Noncoding RNAs and Cardiac Disease",
abstract = "Significance: To maintain homeostasis, gene expression has to be tightly regulated by complex and multiple mechanisms occurring at the epigenetic, transcriptional, and post-transcriptional levels. One crucial regulatory component is represented by long noncoding RNAs (lncRNAs), nonprotein-coding RNA species implicated in all of these levels. Thus, lncRNAs have been associated with any given process or pathway of interest in a variety of systems, including the heart. Recent Advances: Mounting evidence implicates lncRNAs in cardiovascular diseases (CVD) and progression and their presence in the blood of heart disease patients indicates that they are attractive potential biomarkers. Critical Issues: Our understanding of the regulation and molecular mechanisms of action of most lncRNAs remains rudimentary. A challenge is represented by their often low evolutionary sequence conservation that limits the use of animal models for preclinical studies. Nevertheless, a growing number of lncRNAs with an impact on heart function is rapidly accumulating. In this study, we will discuss (i) lncRNAs that control heart homeostasis and disease; (ii) concepts, approaches, and methodologies necessary to study lncRNAs in the heart; and (iii) challenges posed and opportunities presented by lncRNAs as potential therapeutic targets and biomarkers. Future Directions: A deeper knowledge of the molecular mechanisms underpinning CVDs is necessary to develop more effective treatments. Further studies are needed to clarify the regulation and function of lncRNAs in the heart before they can be considered as therapeutic targets and disease biomarkers.",
keywords = "biomarkers, gene expression, heart diseases, long noncoding RNAs",
author = "Simona Greco and Somoza, {Antonio Salgado} and Yvan Devaux and Fabio Martelli",
year = "2018",
month = "9",
day = "20",
doi = "10.1089/ars.2017.7126",
language = "English",
volume = "29",
pages = "880--901",
journal = "Antioxidants and Redox Signaling",
issn = "1523-0864",
publisher = "Mary Ann Liebert Inc.",
number = "9",

}

TY - JOUR

T1 - Long Noncoding RNAs and Cardiac Disease

AU - Greco, Simona

AU - Somoza, Antonio Salgado

AU - Devaux, Yvan

AU - Martelli, Fabio

PY - 2018/9/20

Y1 - 2018/9/20

N2 - Significance: To maintain homeostasis, gene expression has to be tightly regulated by complex and multiple mechanisms occurring at the epigenetic, transcriptional, and post-transcriptional levels. One crucial regulatory component is represented by long noncoding RNAs (lncRNAs), nonprotein-coding RNA species implicated in all of these levels. Thus, lncRNAs have been associated with any given process or pathway of interest in a variety of systems, including the heart. Recent Advances: Mounting evidence implicates lncRNAs in cardiovascular diseases (CVD) and progression and their presence in the blood of heart disease patients indicates that they are attractive potential biomarkers. Critical Issues: Our understanding of the regulation and molecular mechanisms of action of most lncRNAs remains rudimentary. A challenge is represented by their often low evolutionary sequence conservation that limits the use of animal models for preclinical studies. Nevertheless, a growing number of lncRNAs with an impact on heart function is rapidly accumulating. In this study, we will discuss (i) lncRNAs that control heart homeostasis and disease; (ii) concepts, approaches, and methodologies necessary to study lncRNAs in the heart; and (iii) challenges posed and opportunities presented by lncRNAs as potential therapeutic targets and biomarkers. Future Directions: A deeper knowledge of the molecular mechanisms underpinning CVDs is necessary to develop more effective treatments. Further studies are needed to clarify the regulation and function of lncRNAs in the heart before they can be considered as therapeutic targets and disease biomarkers.

AB - Significance: To maintain homeostasis, gene expression has to be tightly regulated by complex and multiple mechanisms occurring at the epigenetic, transcriptional, and post-transcriptional levels. One crucial regulatory component is represented by long noncoding RNAs (lncRNAs), nonprotein-coding RNA species implicated in all of these levels. Thus, lncRNAs have been associated with any given process or pathway of interest in a variety of systems, including the heart. Recent Advances: Mounting evidence implicates lncRNAs in cardiovascular diseases (CVD) and progression and their presence in the blood of heart disease patients indicates that they are attractive potential biomarkers. Critical Issues: Our understanding of the regulation and molecular mechanisms of action of most lncRNAs remains rudimentary. A challenge is represented by their often low evolutionary sequence conservation that limits the use of animal models for preclinical studies. Nevertheless, a growing number of lncRNAs with an impact on heart function is rapidly accumulating. In this study, we will discuss (i) lncRNAs that control heart homeostasis and disease; (ii) concepts, approaches, and methodologies necessary to study lncRNAs in the heart; and (iii) challenges posed and opportunities presented by lncRNAs as potential therapeutic targets and biomarkers. Future Directions: A deeper knowledge of the molecular mechanisms underpinning CVDs is necessary to develop more effective treatments. Further studies are needed to clarify the regulation and function of lncRNAs in the heart before they can be considered as therapeutic targets and disease biomarkers.

KW - biomarkers

KW - gene expression

KW - heart diseases

KW - long noncoding RNAs

UR - http://www.scopus.com/inward/record.url?scp=85051344479&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051344479&partnerID=8YFLogxK

U2 - 10.1089/ars.2017.7126

DO - 10.1089/ars.2017.7126

M3 - Review article

AN - SCOPUS:85051344479

VL - 29

SP - 880

EP - 901

JO - Antioxidants and Redox Signaling

JF - Antioxidants and Redox Signaling

SN - 1523-0864

IS - 9

ER -