Abstract
RNAs not encoding proteins have gained prominence over the last couple of decades as fundamental regulators of cellular function. Not surprisingly, their dysregulation is increasingly being linked to pathology. Here, we review recent reports investigating the pathophysiological relevance of this species of RNA for the cardiovascular system, concentrating mainly on recent findings on long noncoding RNAs and microRNAs in cardiac hypertrophy and failure.
| Original language | English |
|---|---|
| Pages (from-to) | 751-762 |
| Number of pages | 12 |
| Journal | Circulation Research |
| Volume | 116 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Feb 13 2015 |
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Keywords
- Cardiac hypertrophy
- Cardiac remodelling
- Heart failure
- lncRNAs
- MicroRNAs
- Myocardial infarction
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
- Medicine(all)
Cite this
Long noncoding RNAs and microRNAs in cardiovascular pathophysiology. / Thum, Thomas; Condorelli, Gianluigi.
In: Circulation Research, Vol. 116, No. 4, 13.02.2015, p. 751-762.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long noncoding RNAs and microRNAs in cardiovascular pathophysiology
AU - Thum, Thomas
AU - Condorelli, Gianluigi
PY - 2015/2/13
Y1 - 2015/2/13
N2 - RNAs not encoding proteins have gained prominence over the last couple of decades as fundamental regulators of cellular function. Not surprisingly, their dysregulation is increasingly being linked to pathology. Here, we review recent reports investigating the pathophysiological relevance of this species of RNA for the cardiovascular system, concentrating mainly on recent findings on long noncoding RNAs and microRNAs in cardiac hypertrophy and failure.
AB - RNAs not encoding proteins have gained prominence over the last couple of decades as fundamental regulators of cellular function. Not surprisingly, their dysregulation is increasingly being linked to pathology. Here, we review recent reports investigating the pathophysiological relevance of this species of RNA for the cardiovascular system, concentrating mainly on recent findings on long noncoding RNAs and microRNAs in cardiac hypertrophy and failure.
KW - Cardiac hypertrophy
KW - Cardiac remodelling
KW - Heart failure
KW - lncRNAs
KW - MicroRNAs
KW - Myocardial infarction
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UR - http://www.scopus.com/inward/citedby.url?scp=84924145079&partnerID=8YFLogxK
U2 - 10.1161/CIRCRESAHA.116.303549
DO - 10.1161/CIRCRESAHA.116.303549
M3 - Article
C2 - 25677521
AN - SCOPUS:84924145079
VL - 116
SP - 751
EP - 762
JO - Circulation Research
JF - Circulation Research
SN - 0009-7330
IS - 4
ER -