Long noncoding RNAs and microRNAs in cardiovascular pathophysiology

Research output: Contribution to journalArticle

186 Citations (Scopus)

Abstract

RNAs not encoding proteins have gained prominence over the last couple of decades as fundamental regulators of cellular function. Not surprisingly, their dysregulation is increasingly being linked to pathology. Here, we review recent reports investigating the pathophysiological relevance of this species of RNA for the cardiovascular system, concentrating mainly on recent findings on long noncoding RNAs and microRNAs in cardiac hypertrophy and failure.

Original languageEnglish
Pages (from-to)751-762
Number of pages12
JournalCirculation Research
Volume116
Issue number4
DOIs
Publication statusPublished - Feb 13 2015

Fingerprint

Long Noncoding RNA
MicroRNAs
RNA
Cardiomegaly
Cardiovascular System
Heart Failure
Pathology
Proteins

Keywords

  • Cardiac hypertrophy
  • Cardiac remodelling
  • Heart failure
  • lncRNAs
  • MicroRNAs
  • Myocardial infarction

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Long noncoding RNAs and microRNAs in cardiovascular pathophysiology. / Thum, Thomas; Condorelli, Gianluigi.

In: Circulation Research, Vol. 116, No. 4, 13.02.2015, p. 751-762.

Research output: Contribution to journalArticle

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