Long noncoding RNAs, emerging players in muscle differentiation and disease

Maria V. Neguembor, Mathivanan Jothi, Davide Gabellini

Research output: Contribution to journalArticle

Abstract

The vast majority of the mammalian genome is transcribed giving rise to many different types of noncoding RNAs. Among them, long noncoding RNAs are the most numerous and functionally versatile class. Indeed, the lncRNA repertoire might be as rich as the proteome. LncRNAs have emerged as key regulators of gene expression at multiple levels. They play important roles in the regulation of development, differentiation and maintenance of cell identity and they also contribute to disease. In this review, we present recent advances in the biology of lncRNAs in muscle development and differentiation. We will also discuss the contribution of lncRNAs to muscle disease with a particular focus on Duchenne and facioscapulohumeral muscular dystrophies.

Original languageEnglish
Article number8
JournalSkeletal Muscle
Volume4
Issue number1
DOIs
Publication statusPublished - Mar 31 2014

Keywords

  • Chromatin
  • DMD
  • FSHD
  • Muscular dystrophy
  • ncRNA
  • Repeat

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Orthopedics and Sports Medicine

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