Long-QT syndrome after age 40

Ilan Goldenberg; Arthur J. Moss; Derick R. Peterson; Scott McNitt; Wojciech Zareba; Mark L. Andrews; Jennifer L. Robinson; Emanuela H. Locati; Michael J. Ackerman; Jesaia Benhorin; Elizabeth S. Kaufman; Carlo Napolitano; Silvia G. Priori; Ming Qi; Peter J. Schwartz; Jeffrey A. Towbin; G. Michael Vincent; Li Zhang

doi:10.1161/CIRCULATIONAHA.107.729368

Long-QT syndrome after age 40

Ilan Goldenberg, Arthur J. Moss, Derick R. Peterson, Scott McNitt, Wojciech Zareba, Mark L. Andrews, Jennifer L. Robinson, Emanuela H. Locati, Michael J. Ackerman, Jesaia Benhorin, Elizabeth S. Kaufman, Carlo Napolitano, Silvia G. Priori, Ming Qi, Peter J. Schwartz, Jeffrey A. Towbin, G. Michael Vincent, Li Zhang

Research output: Contribution to journal › Article › peer-review

Abstract

Background-Previous studies that assessed the risk of life-threatening cardiac events in patients with congenital long-QT syndrome (LQTS) have focused mainly on the first 4 decades of life, whereas the clinical course of this inherited cardiac disorder in the older population has not been studied. Methods and Results-The risk of aborted cardiac arrest or death from age 41 though 75 years was assessed in 2759 subjects from the International LQTS Registry, categorized into electrocardiographically affected (corrected QT interval [QTc] ≥470 ms), borderline (QTc 440 to 469 ms), and unaffected (QTc

Original language	English
Pages (from-to)	2192-2201
Number of pages	10
Journal	Circulation
Volume	117
Issue number	17
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.107.729368
Publication status	Published - Apr 29 2008

Keywords

Long-QT syndrome
Mortality
Risk factors

ASJC Scopus subject areas

Physiology (medical)
Cardiology and Cardiovascular Medicine
Physiology

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10.1161/CIRCULATIONAHA.107.729368

Cite this

Goldenberg, I., Moss, A. J., Peterson, D. R., McNitt, S., Zareba, W., Andrews, M. L., Robinson, J. L., Locati, E. H., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Napolitano, C., Priori, S. G., Qi, M., Schwartz, P. J., Towbin, J. A., Vincent, G. M., & Zhang, L. (2008). Long-QT syndrome after age 40. Circulation, 117(17), 2192-2201. https://doi.org/10.1161/CIRCULATIONAHA.107.729368

Long-QT syndrome after age 40. / Goldenberg, Ilan; Moss, Arthur J.; Peterson, Derick R.; McNitt, Scott; Zareba, Wojciech; Andrews, Mark L.; Robinson, Jennifer L.; Locati, Emanuela H.; Ackerman, Michael J.; Benhorin, Jesaia; Kaufman, Elizabeth S.; Napolitano, Carlo; Priori, Silvia G.; Qi, Ming; Schwartz, Peter J.; Towbin, Jeffrey A.; Vincent, G. Michael; Zhang, Li.

In: Circulation, Vol. 117, No. 17, 29.04.2008, p. 2192-2201.

Research output: Contribution to journal › Article › peer-review

Goldenberg, Ilan ; Moss, Arthur J. ; Peterson, Derick R. ; McNitt, Scott ; Zareba, Wojciech ; Andrews, Mark L. ; Robinson, Jennifer L. ; Locati, Emanuela H. ; Ackerman, Michael J. ; Benhorin, Jesaia ; Kaufman, Elizabeth S. ; Napolitano, Carlo ; Priori, Silvia G. ; Qi, Ming ; Schwartz, Peter J. ; Towbin, Jeffrey A. ; Vincent, G. Michael ; Zhang, Li. / Long-QT syndrome after age 40. In: Circulation. 2008 ; Vol. 117, No. 17. pp. 2192-2201.

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abstract = "Background-Previous studies that assessed the risk of life-threatening cardiac events in patients with congenital long-QT syndrome (LQTS) have focused mainly on the first 4 decades of life, whereas the clinical course of this inherited cardiac disorder in the older population has not been studied. Methods and Results-The risk of aborted cardiac arrest or death from age 41 though 75 years was assessed in 2759 subjects from the International LQTS Registry, categorized into electrocardiographically affected (corrected QT interval [QTc] ≥470 ms), borderline (QTc 440 to 469 ms), and unaffected (QTc ",

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AU - Robinson, Jennifer L.

AU - Locati, Emanuela H.

AU - Ackerman, Michael J.

AU - Benhorin, Jesaia

AU - Kaufman, Elizabeth S.

AU - Napolitano, Carlo

AU - Priori, Silvia G.

AU - Qi, Ming

AU - Schwartz, Peter J.

AU - Towbin, Jeffrey A.

AU - Vincent, G. Michael

AU - Zhang, Li

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Long-QT syndrome after age 40

Abstract

Keywords

ASJC Scopus subject areas

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