Long-QT syndrome after age 40

Ilan Goldenberg, Arthur J. Moss, Derick R. Peterson, Scott McNitt, Wojciech Zareba, Mark L. Andrews, Jennifer L. Robinson, Emanuela H. Locati, Michael J. Ackerman, Jesaia Benhorin, Elizabeth S. Kaufman, Carlo Napolitano, Silvia G. Priori, Ming Qi, Peter J. Schwartz, Jeffrey A. Towbin, G. Michael Vincent, Li Zhang

Research output: Contribution to journalArticle

Abstract

Background-Previous studies that assessed the risk of life-threatening cardiac events in patients with congenital long-QT syndrome (LQTS) have focused mainly on the first 4 decades of life, whereas the clinical course of this inherited cardiac disorder in the older population has not been studied. Methods and Results-The risk of aborted cardiac arrest or death from age 41 though 75 years was assessed in 2759 subjects from the International LQTS Registry, categorized into electrocardiographically affected (corrected QT interval [QTc] ≥470 ms), borderline (QTc 440 to 469 ms), and unaffected (QTc

Original languageEnglish
Pages (from-to)2192-2201
Number of pages10
JournalCirculation
Volume117
Issue number17
DOIs
Publication statusPublished - Apr 29 2008

Keywords

  • Long-QT syndrome
  • Mortality
  • Risk factors

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine
  • Physiology

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  • Cite this

    Goldenberg, I., Moss, A. J., Peterson, D. R., McNitt, S., Zareba, W., Andrews, M. L., Robinson, J. L., Locati, E. H., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Napolitano, C., Priori, S. G., Qi, M., Schwartz, P. J., Towbin, J. A., Vincent, G. M., & Zhang, L. (2008). Long-QT syndrome after age 40. Circulation, 117(17), 2192-2201. https://doi.org/10.1161/CIRCULATIONAHA.107.729368