Long-standing multiple sclerosis neurodegeneration: volumetric magnetic resonance imaging comparison to Parkinson's disease, mild cognitive impairment, Alzheimer's disease, and elderly healthy controls

Dejan Jakimovski, Niels Bergsland, Michael G. Dwyer, Jesper Hagemeier, Deepa P. Ramasamy, Kinga Szigeti, Thomas Guttuso, David Lichter, David Hojnacki, Bianca Weinstock-Guttman, Ralph H.B. Benedict, Robert Zivadinov

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple sclerosis (MS) exhibits neurodegeneration driven disability progression. We compared the extent of neurodegeneration among 112 long-standing MS patients, 37 Parkinson's disease (PD) patients, 34 amnestic mild cognitive impairment (aMCI) patients, 37 Alzheimer's disease (AD) patients, and 184 healthy controls. 3T MRI volumes of whole brain (WBV), white matter (WMV), gray matter (GMV), cortical (CV), deep gray matter (DGM), and nuclei-specific volumes of thalamus, caudate, putamen, globus pallidus, and hippocampus were derived with SIENAX and FIRST software. Аge and sex-adjusted analysis of covariance was used. WBV was not significantly different between diseases. MS had significantly lower WMV compared to other disease groups (p < 0.021). Only AD had smaller GMV and CV when compared to MS (both p < 0.001). MS had smaller DGM volume than PD and aMCI (p < 0.001 and p = 0.026, respectively) and lower thalamic volume when compared to all other neurodegenerative diseases (p < 0.008). Long-standing MS exhibits comparable global atrophy with lower WMV and thalamic volume when compared to other classical neurodegenerative diseases.

Original languageEnglish
Pages (from-to)84-92
Number of pages9
JournalNeurobiology of Aging
Volume90
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Alzheimer's disease
  • Deep gray matter
  • MRI
  • Multiple sclerosis
  • Neurodegeneration
  • Parkinson's disease
  • Thalamus
  • Whole brain atrophy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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