Long-term (≥10 years) safety of percutaneous treatment of unprotected left main stenosis with drug-eluting stents

Imad Sheiban, Claudio Moretti, Fabrizio D'Ascenzo, Alaide Chieffo, Salma Taha, Stephen O. Connor, Sujaysubash Chandran, Jm De La Torre Hernández, Sl Chen, Ferdinando Varbella, Pierluigi Omedè, Mario Iannaccone, Emanuele Meliga, Hiroyoshi Kawamoto, Antonio Montefusco, Chong Mervyn, Philippe Garot, Lin Sin, Valeria Gasparetto, Mohamed AbdirashidEnrico Cerrato, Giuseppe Biondi Zoccai, Fiorenzo Gaita, Javier Escaned, David Hiddick Smith, Thierry Lefèvre, Antonio Colombo

Research output: Contribution to journalArticle

Abstract

Percutaneous coronary intervention (PCI) of unprotected left main disease (Ulm) with drug-eluting stents (DES) is hampered by lack of information on long-term (≥10 years) safety data. All patients treated with PCI on Ulm in 9 international centers with at least 10 years follow-up were enrolled. Baseline and procedural features were recorded. Repeat PCI (re-PCI) on Ulm at 10 years was the primary end point. Secondary end points included major adverse cardiac events and its components (cardiac and noncardiac death, myocardial infarction, re-PCI not on Ulm, and stent thrombosis). Sensitivity analysis was performed according to the presence of isolated Ulm disease: 284 patients were enrolled. A total of 70 patients (21%) performed a re-PCI on Ulm, 39 in the first year, and 31 between 1 and 10 years (only 5 overall performed for acute coronary syndrome). Patients with re-PCI on Ulm did not show differences in baseline and procedural features, or experience higher rates of cardiovascular death (12% vs 11%, p 0.65), myocardial infarction (11% vs 6%, p 0.56), or of re-PCI on non-Ulm disease (31% vs 27%, p 0.76) compared with those without re-PCI on Ulm. At Kaplan-Meier analysis, patients with PCI in other coronary vessels were at higher risk of major adverse cardiac events, driven by target vessel revascularization (20.4% vs 32.9%, p 0.009), as confirmed at multivariate analysis (stenosis other than LM; hazard ratio 2, 1.4 to 2.7, all CI 95%). In conclusion, despite of using first-generation stents, PCI on Ulm is safe, with low rates of recurrent events due to index revascularization. Progression of atherosclerotic lesions on other coronary vessels represents the only independent predictive factor for prognosis.

Original languageEnglish
Pages (from-to)32-39
Number of pages8
JournalAmerican Journal of Cardiology
Volume118
Issue number1
DOIs
Publication statusPublished - Jul 1 2016

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Sheiban, I., Moretti, C., D'Ascenzo, F., Chieffo, A., Taha, S., Connor, S. O., Chandran, S., De La Torre Hernández, J., Chen, S., Varbella, F., Omedè, P., Iannaccone, M., Meliga, E., Kawamoto, H., Montefusco, A., Mervyn, C., Garot, P., Sin, L., Gasparetto, V., ... Colombo, A. (2016). Long-term (≥10 years) safety of percutaneous treatment of unprotected left main stenosis with drug-eluting stents. American Journal of Cardiology, 118(1), 32-39. https://doi.org/10.1016/j.amjcard.2016.04.007