Long-term (≥8 years) outcome after Palmaz-Schatz stent implantation

Rémi Choussat, Catherine Klersy, A. J R Black, Irene Bossi, Jean Pierre Laurent, Christian Jordan, Giulio Guagliumi, Jean Fajadet, Jean Marco

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this single-center study was to evaluate the long-term (≥8 years) outcome of Palmaz-Schatz intracoronary stenting and to identify independent predictors of outcome. Although short-term results of Palmaz-Schatz intracoronary stenting have been promising, with a reduction in both angiographic restenosis and clinical cardiac events up to 3 years, longer-term follow-up has not been established. We analyzed clinical outcome in 426 consecutive patients at least 8 years after coronary stenting. Demographic, clinical, and procedural predictors of restenosis, survival, and event-free survival, defined as freedom from death, myocardial infarction (MI), and coronary revascularization (target stented site, target vessel, and any revascularization) were analyzed. Before discharge, 28 patients (6.6%) sustained at least 1 major cardiovascular event: 3 deaths (0.7%), 18 MIs (4.2%), and 17 repeat revascularizations. Surviving patients were followed for 8.9 years (interquartile range 8.4 to 9.4). After discharge, 59 patients (13.9%) died, 47 (11.1%) sustained an MI, and 188 (44.4%) underwent coronary revascularization. The 8-year event-free survival (freedom from death, freedom from death/MI/target-stented site revascularization, and freedom from death/MI/any coronary revascularization) was (mean ± SE) 0.86 ± 0.01, 0.62 ± 0.03, and 0.47 ± 0.02, respectively. Unstable angina, lower left ventricular ejection fraction, and saphenous vein graft stenting were found to be independent predictors of death during follow-up. Hypertension, unstable angina, multivessel disease, and multiple stent implantation were found to be independent predictors of the composite of death/MI/any coronary revascularization during follow-up. This study provided a useful assessment of very long-term outcome in survival, event-free survival, and predictors of major cardiac events 8 to 10 years after Palmaz-Schatz stent implantation.

Original languageEnglish
Pages (from-to)10-16
Number of pages7
JournalThe American Journal of Cardiology
Volume88
Issue number1
DOIs
Publication statusPublished - Jul 1 2001

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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