Long-term beneficial effect of islet transplantation on diabetic macro-/microangiopathy in type 1 diabetic kidney-transplanted patients

Paolo Fiorina, Franco Folli, Federico Bertuzzi, Paola Maffi, Giovanna Finzi, Massimo Venturini, Carlo Socci, Alberto Davalli, Elena Orsenigo, Lucilla Monti, Luca Falqui, Silvia Uccella, Stefano La Rosa, Luciana Usellini, Giuliana Properzi, Valerio Di Carlo, Alessandro Del Maschio, Carlo Capella, Antonio Secchi

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

OBJECTIVE - Our aim was to evaluate the long-term effects of transplanted islets on diabetic macro-/microangiopathy in type 1 diabetic kidney-transplanted patients. RESEARCH DESIGN AND METHODS - A total of 34 type 1 diabetic kidney-transplanted patients underwent islet transplantation and were divided into two groups: successful islet-kidney transplantation (SI-K; 21 patients, fasting C-peptide serum concentration >0.5 ng/ml for >1 year) and unsuccessful islet-kidney transplantation (UI-K; 13 patients, fasting C-peptide serum concentration 2 = 3.9, P = 0.04), and lower intima-media thickness progression than the UI-K group (SI-K group: Δ1-3 -years 13 ± 30 μm vs. UI-K group: A 1-3 years 245 ± 20 μm, P = 0.03) with decreased signs of endothelial injuring at skin biopsy. Furthermore, the SI-K group showed a higher EDD than the UI-K group (EDD: SI-K 7.8 ± 4.5% vs. UI-K 0.5 ± 2.7%, P = 0.02), higher basal NO (SI-K 42.9 ± 6.5 vs. UI-K 20.2 ± 6.8 μmol/l, P = 0.02), and lower levels of vWF (SI-K 138.6 ± 15.3 vs. UI-K 180.6 ± 7.0%, P = 0.02) and DDF (SI-K 0.61 ± 0.22 vs. UI-K 3.07 ± 0.68 μg/ml, P <0.01). C-peptide-to-creatinine ratio correlated positively with EDD and NO and negatively with vWF and DDF. CONCLUSIONS - Successful islet transplantation improves survival, cardiovascular, and endothelial function in type 1 diabetic kidney-transplanted patients.

Original languageEnglish
Pages (from-to)1129-1136
Number of pages8
JournalDiabetes Care
Volume26
Issue number4
DOIs
Publication statusPublished - Apr 1 2003

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Diabetic Angiopathies
Islets of Langerhans Transplantation
C-Peptide
Kidney
Kidney Transplantation
Fasting
Serum
Creatinine
Research Design
Biopsy
Skin
Survival

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Long-term beneficial effect of islet transplantation on diabetic macro-/microangiopathy in type 1 diabetic kidney-transplanted patients. / Fiorina, Paolo; Folli, Franco; Bertuzzi, Federico; Maffi, Paola; Finzi, Giovanna; Venturini, Massimo; Socci, Carlo; Davalli, Alberto; Orsenigo, Elena; Monti, Lucilla; Falqui, Luca; Uccella, Silvia; La Rosa, Stefano; Usellini, Luciana; Properzi, Giuliana; Di Carlo, Valerio; Del Maschio, Alessandro; Capella, Carlo; Secchi, Antonio.

In: Diabetes Care, Vol. 26, No. 4, 01.04.2003, p. 1129-1136.

Research output: Contribution to journalArticle

Fiorina, P, Folli, F, Bertuzzi, F, Maffi, P, Finzi, G, Venturini, M, Socci, C, Davalli, A, Orsenigo, E, Monti, L, Falqui, L, Uccella, S, La Rosa, S, Usellini, L, Properzi, G, Di Carlo, V, Del Maschio, A, Capella, C & Secchi, A 2003, 'Long-term beneficial effect of islet transplantation on diabetic macro-/microangiopathy in type 1 diabetic kidney-transplanted patients', Diabetes Care, vol. 26, no. 4, pp. 1129-1136. https://doi.org/10.2337/diacare.26.4.1129
Fiorina, Paolo ; Folli, Franco ; Bertuzzi, Federico ; Maffi, Paola ; Finzi, Giovanna ; Venturini, Massimo ; Socci, Carlo ; Davalli, Alberto ; Orsenigo, Elena ; Monti, Lucilla ; Falqui, Luca ; Uccella, Silvia ; La Rosa, Stefano ; Usellini, Luciana ; Properzi, Giuliana ; Di Carlo, Valerio ; Del Maschio, Alessandro ; Capella, Carlo ; Secchi, Antonio. / Long-term beneficial effect of islet transplantation on diabetic macro-/microangiopathy in type 1 diabetic kidney-transplanted patients. In: Diabetes Care. 2003 ; Vol. 26, No. 4. pp. 1129-1136.
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abstract = "OBJECTIVE - Our aim was to evaluate the long-term effects of transplanted islets on diabetic macro-/microangiopathy in type 1 diabetic kidney-transplanted patients. RESEARCH DESIGN AND METHODS - A total of 34 type 1 diabetic kidney-transplanted patients underwent islet transplantation and were divided into two groups: successful islet-kidney transplantation (SI-K; 21 patients, fasting C-peptide serum concentration >0.5 ng/ml for >1 year) and unsuccessful islet-kidney transplantation (UI-K; 13 patients, fasting C-peptide serum concentration 2 = 3.9, P = 0.04), and lower intima-media thickness progression than the UI-K group (SI-K group: Δ1-3 -years 13 ± 30 μm vs. UI-K group: A 1-3 years 245 ± 20 μm, P = 0.03) with decreased signs of endothelial injuring at skin biopsy. Furthermore, the SI-K group showed a higher EDD than the UI-K group (EDD: SI-K 7.8 ± 4.5{\%} vs. UI-K 0.5 ± 2.7{\%}, P = 0.02), higher basal NO (SI-K 42.9 ± 6.5 vs. UI-K 20.2 ± 6.8 μmol/l, P = 0.02), and lower levels of vWF (SI-K 138.6 ± 15.3 vs. UI-K 180.6 ± 7.0{\%}, P = 0.02) and DDF (SI-K 0.61 ± 0.22 vs. UI-K 3.07 ± 0.68 μg/ml, P <0.01). C-peptide-to-creatinine ratio correlated positively with EDD and NO and negatively with vWF and DDF. CONCLUSIONS - Successful islet transplantation improves survival, cardiovascular, and endothelial function in type 1 diabetic kidney-transplanted patients.",
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T1 - Long-term beneficial effect of islet transplantation on diabetic macro-/microangiopathy in type 1 diabetic kidney-transplanted patients

AU - Fiorina, Paolo

AU - Folli, Franco

AU - Bertuzzi, Federico

AU - Maffi, Paola

AU - Finzi, Giovanna

AU - Venturini, Massimo

AU - Socci, Carlo

AU - Davalli, Alberto

AU - Orsenigo, Elena

AU - Monti, Lucilla

AU - Falqui, Luca

AU - Uccella, Silvia

AU - La Rosa, Stefano

AU - Usellini, Luciana

AU - Properzi, Giuliana

AU - Di Carlo, Valerio

AU - Del Maschio, Alessandro

AU - Capella, Carlo

AU - Secchi, Antonio

PY - 2003/4/1

Y1 - 2003/4/1

N2 - OBJECTIVE - Our aim was to evaluate the long-term effects of transplanted islets on diabetic macro-/microangiopathy in type 1 diabetic kidney-transplanted patients. RESEARCH DESIGN AND METHODS - A total of 34 type 1 diabetic kidney-transplanted patients underwent islet transplantation and were divided into two groups: successful islet-kidney transplantation (SI-K; 21 patients, fasting C-peptide serum concentration >0.5 ng/ml for >1 year) and unsuccessful islet-kidney transplantation (UI-K; 13 patients, fasting C-peptide serum concentration 2 = 3.9, P = 0.04), and lower intima-media thickness progression than the UI-K group (SI-K group: Δ1-3 -years 13 ± 30 μm vs. UI-K group: A 1-3 years 245 ± 20 μm, P = 0.03) with decreased signs of endothelial injuring at skin biopsy. Furthermore, the SI-K group showed a higher EDD than the UI-K group (EDD: SI-K 7.8 ± 4.5% vs. UI-K 0.5 ± 2.7%, P = 0.02), higher basal NO (SI-K 42.9 ± 6.5 vs. UI-K 20.2 ± 6.8 μmol/l, P = 0.02), and lower levels of vWF (SI-K 138.6 ± 15.3 vs. UI-K 180.6 ± 7.0%, P = 0.02) and DDF (SI-K 0.61 ± 0.22 vs. UI-K 3.07 ± 0.68 μg/ml, P <0.01). C-peptide-to-creatinine ratio correlated positively with EDD and NO and negatively with vWF and DDF. CONCLUSIONS - Successful islet transplantation improves survival, cardiovascular, and endothelial function in type 1 diabetic kidney-transplanted patients.

AB - OBJECTIVE - Our aim was to evaluate the long-term effects of transplanted islets on diabetic macro-/microangiopathy in type 1 diabetic kidney-transplanted patients. RESEARCH DESIGN AND METHODS - A total of 34 type 1 diabetic kidney-transplanted patients underwent islet transplantation and were divided into two groups: successful islet-kidney transplantation (SI-K; 21 patients, fasting C-peptide serum concentration >0.5 ng/ml for >1 year) and unsuccessful islet-kidney transplantation (UI-K; 13 patients, fasting C-peptide serum concentration 2 = 3.9, P = 0.04), and lower intima-media thickness progression than the UI-K group (SI-K group: Δ1-3 -years 13 ± 30 μm vs. UI-K group: A 1-3 years 245 ± 20 μm, P = 0.03) with decreased signs of endothelial injuring at skin biopsy. Furthermore, the SI-K group showed a higher EDD than the UI-K group (EDD: SI-K 7.8 ± 4.5% vs. UI-K 0.5 ± 2.7%, P = 0.02), higher basal NO (SI-K 42.9 ± 6.5 vs. UI-K 20.2 ± 6.8 μmol/l, P = 0.02), and lower levels of vWF (SI-K 138.6 ± 15.3 vs. UI-K 180.6 ± 7.0%, P = 0.02) and DDF (SI-K 0.61 ± 0.22 vs. UI-K 3.07 ± 0.68 μg/ml, P <0.01). C-peptide-to-creatinine ratio correlated positively with EDD and NO and negatively with vWF and DDF. CONCLUSIONS - Successful islet transplantation improves survival, cardiovascular, and endothelial function in type 1 diabetic kidney-transplanted patients.

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