Abstract
Objectives The aim of the present study is to determine the long-term effects of a ten-week exercise training program in adult patients with a systemic right ventricle. Methods All patients who participated in a 2009 randomized controlled trial were approached. At approximately three years of follow-up from initial baseline, patients underwent cardiopulmonary exercise testing, filled out two quality of life questionnaires, and NT proBNP levels were measured. All examinations were performed according to the protocols of the 2009 trial. In addition, patients were asked about their current sports habits. Results Of the 54 patients who were randomized in the 2009-trial 40 participated in the current re-evaluation (male 50%, ccTGA 35%, age 36 ± 10 years, intervention group n = 22, control group n = 18). After three years, no persistent effect of exercise training on V'O2peak training remained (- 2% of predicted, 95% CI - 3% to 5%; p =.56). However, patients who already participated in regular sports or exercise at baseline (n = 23/40 (58%)) showed higher V'O2peak of 13% of predicted (95% CI 4% to 23%; p >.01) and a decrease of 62% in plasma NT-proBNP (95% CI - 115% to - 10%; p >.03) during follow-up, when compared to patients who did not. Moreover, sports were associated with a lower incidence of clinical events (p =.032). Conclusion Short-term beneficial effects of exercise training did not persist over a three-year follow-up period. However, sports participation at baseline was associated with better exercise capacity, lower neurohormone levels, and increased event-free survival.
| Original language | English |
|---|---|
| Pages (from-to) | 105-111 |
| Number of pages | 7 |
| Journal | International Journal of Cardiology |
| Volume | 179 |
| DOIs | |
| Publication status | Published - Jan 20 2015 |
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Keywords
- Congenital heart disease
- Exercise Sports
- Systemic right ventricle
- Transposition of the great arteries
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Medicine(all)
Cite this
Long-term benefits of exercise training in patients with a systemic right ventricle. / Van Der Bom, Teun; Winter, Michiel M.; Knaake, Jennifer L.; Cervi, Elena; De Vries, Leonie S C; Balducci, Anna; Meregalli, Paola G.; Pieper, Petronella G.; Van Dijk, Arie P J; Bonvicini, Marco; Mulder, Barbara J M; Bouma, Berto J.
In: International Journal of Cardiology, Vol. 179, 20.01.2015, p. 105-111.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term benefits of exercise training in patients with a systemic right ventricle
AU - Van Der Bom, Teun
AU - Winter, Michiel M.
AU - Knaake, Jennifer L.
AU - Cervi, Elena
AU - De Vries, Leonie S C
AU - Balducci, Anna
AU - Meregalli, Paola G.
AU - Pieper, Petronella G.
AU - Van Dijk, Arie P J
AU - Bonvicini, Marco
AU - Mulder, Barbara J M
AU - Bouma, Berto J.
PY - 2015/1/20
Y1 - 2015/1/20
N2 - Objectives The aim of the present study is to determine the long-term effects of a ten-week exercise training program in adult patients with a systemic right ventricle. Methods All patients who participated in a 2009 randomized controlled trial were approached. At approximately three years of follow-up from initial baseline, patients underwent cardiopulmonary exercise testing, filled out two quality of life questionnaires, and NT proBNP levels were measured. All examinations were performed according to the protocols of the 2009 trial. In addition, patients were asked about their current sports habits. Results Of the 54 patients who were randomized in the 2009-trial 40 participated in the current re-evaluation (male 50%, ccTGA 35%, age 36 ± 10 years, intervention group n = 22, control group n = 18). After three years, no persistent effect of exercise training on V'O2peak training remained (- 2% of predicted, 95% CI - 3% to 5%; p =.56). However, patients who already participated in regular sports or exercise at baseline (n = 23/40 (58%)) showed higher V'O2peak of 13% of predicted (95% CI 4% to 23%; p >.01) and a decrease of 62% in plasma NT-proBNP (95% CI - 115% to - 10%; p >.03) during follow-up, when compared to patients who did not. Moreover, sports were associated with a lower incidence of clinical events (p =.032). Conclusion Short-term beneficial effects of exercise training did not persist over a three-year follow-up period. However, sports participation at baseline was associated with better exercise capacity, lower neurohormone levels, and increased event-free survival.
AB - Objectives The aim of the present study is to determine the long-term effects of a ten-week exercise training program in adult patients with a systemic right ventricle. Methods All patients who participated in a 2009 randomized controlled trial were approached. At approximately three years of follow-up from initial baseline, patients underwent cardiopulmonary exercise testing, filled out two quality of life questionnaires, and NT proBNP levels were measured. All examinations were performed according to the protocols of the 2009 trial. In addition, patients were asked about their current sports habits. Results Of the 54 patients who were randomized in the 2009-trial 40 participated in the current re-evaluation (male 50%, ccTGA 35%, age 36 ± 10 years, intervention group n = 22, control group n = 18). After three years, no persistent effect of exercise training on V'O2peak training remained (- 2% of predicted, 95% CI - 3% to 5%; p =.56). However, patients who already participated in regular sports or exercise at baseline (n = 23/40 (58%)) showed higher V'O2peak of 13% of predicted (95% CI 4% to 23%; p >.01) and a decrease of 62% in plasma NT-proBNP (95% CI - 115% to - 10%; p >.03) during follow-up, when compared to patients who did not. Moreover, sports were associated with a lower incidence of clinical events (p =.032). Conclusion Short-term beneficial effects of exercise training did not persist over a three-year follow-up period. However, sports participation at baseline was associated with better exercise capacity, lower neurohormone levels, and increased event-free survival.
KW - Congenital heart disease
KW - Exercise Sports
KW - Systemic right ventricle
KW - Transposition of the great arteries
UR - http://www.scopus.com/inward/record.url?scp=84920698534&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920698534&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2014.10.042
DO - 10.1016/j.ijcard.2014.10.042
M3 - Article
VL - 179
SP - 105
EP - 111
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -