TY - JOUR
T1 - Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models
AU - Zaghini, Anna
AU - Sarli, Giuseppe
AU - Barboni, Catia
AU - Sanapo, Mara
AU - Pellegrino, Valeria
AU - Diana, Alessia
AU - Linta, Nikolina
AU - Rambaldi, Julie
AU - D'Apice, Maria Rosaria
AU - Murdocca, Michela
AU - Baleani, Massimiliano
AU - Baruffaldi, Fabio
AU - Fognani, Roberta
AU - Mecca, Rosaria
AU - Festa, Anna
AU - Papparella, Serenella
AU - Paciello, Orlando
AU - Prisco, Francesco
AU - Capanni, Cristina
AU - Loi, Manuela
AU - Schena, Elisa
AU - Lattanzi, Giovanna
AU - Squarzoni, Stefano
N1 - Copyright © 2019. Published by Elsevier Inc.
PY - 2019/11/30
Y1 - 2019/11/30
N2 - The transgenic LmnaG609G progeric mouse represents an outstanding animal model for studying the human Hutchinson-Gilford Progeria Syndrome (HGPS) caused by a mutation in the LMNA gene, coding for the nuclear envelope protein Lamin A/C, and, as an important, more general scope, for studying the complex process governing physiological aging in humans. Here we give a comprehensive description of the peculiarities related to the breeding of LmnaG609G mice over a prolonged period of time, and of many features observed in a large colony for a 2-years period. We describe the breeding and housing conditions underlining the possible interference of the genetic background on the phenotype expression. This information represents a useful tool when planning and interpreting studies on the LmnaG609G mouse model, complementing any specific data already reported in the literature about this model since its production. It is also particularly relevant for the heterozygous mouse, which mirrors the genotype of the human pathology however requires an extended time to manifest symptoms and to be carefully studied.
AB - The transgenic LmnaG609G progeric mouse represents an outstanding animal model for studying the human Hutchinson-Gilford Progeria Syndrome (HGPS) caused by a mutation in the LMNA gene, coding for the nuclear envelope protein Lamin A/C, and, as an important, more general scope, for studying the complex process governing physiological aging in humans. Here we give a comprehensive description of the peculiarities related to the breeding of LmnaG609G mice over a prolonged period of time, and of many features observed in a large colony for a 2-years period. We describe the breeding and housing conditions underlining the possible interference of the genetic background on the phenotype expression. This information represents a useful tool when planning and interpreting studies on the LmnaG609G mouse model, complementing any specific data already reported in the literature about this model since its production. It is also particularly relevant for the heterozygous mouse, which mirrors the genotype of the human pathology however requires an extended time to manifest symptoms and to be carefully studied.
KW - Aging
KW - Animal model breeding
KW - Bone strength
KW - Hutchinson-Gilford Progeria Syndrome (HGPS)
KW - Kyphosis
KW - Quality of life
U2 - 10.1016/j.exger.2019.110784
DO - 10.1016/j.exger.2019.110784
M3 - Article
C2 - 31794853
VL - 130
SP - 1
EP - 18
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
ER -