Long-term changes in left ventricular mass, chamber site and function after valve replacement in patients with severe aortic stenosis and depressed ejection fraction

Giovanna Pelà, Giovanni La Canna, Marco Metra, Claudio Ceconi, Piero Berra Centurini, Ottavio Alfieri, Odoardo Visioli

Research output: Contribution to journalArticlepeer-review

Abstract

We studied 21 patients undergoing valve replacement for severe aortic stenosis and marked left ventricular dysfunction (mean ejection fraction 27 ± 7.9%) without significant coronary disease or other valve diseases. At 5-60 months (average 26 ± 18) after surgery, the patients underwent a clinical history, physical examination and a complete M-mode, two-dimensional and Doppler transthoracic echocardiographic study. Thirteen patients were examined with cardiopulmonary exercise testing. Two patients with a low preoperative transvalvular pressure gradient (<50 mmHg) died postoperatively. Nineteen patients were tested at follow-up. All patients showed an improvement in functional class, an increase in ejection fraction (EF), a normalization in left ventricular diameters, volumes and stress indices and a reduction in left ventricular mass which correlated with EF increase. Cardiopulmonary exercise testing showed a good exercise capacity. In conclusion, in patients affected by severe aortic stenosis and marked preoperative left ventricular dysfunction valve replacement induces a favorable remodeling of the left ventricle, as shown by a late postoperative examination. The regression of hypertrophy is a positive event which correlates with the improvement in EF.

Original languageEnglish
Pages (from-to)315-322
Number of pages8
JournalCardiology
Volume88
Issue number4
Publication statusPublished - 1997

Keywords

  • Aortic stenosis
  • Aortic valve replacement
  • Left ventricular dysfunction
  • Morphological changes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Long-term changes in left ventricular mass, chamber site and function after valve replacement in patients with severe aortic stenosis and depressed ejection fraction'. Together they form a unique fingerprint.

Cite this