Long-term clinical and functional impact of biliopancreatic diversion on type 2 diabetes in morbidly and non-morbidly obese patients

Nicola Scopinaro, Giovanni Camerini, Francesco Papadia, Gabriella Andraghetti, Renzo Cordera, Gian Franco Adami

Research output: Contribution to journalArticle

Abstract

Setting: Obesity surgery has been proposed as a treatment option for diabetic patients with body mass index (BMI)2, but the efficacy of metabolic surgery has not been conclusively determined. Objective: To evaluate the long-term metabolic outcome of non-morbidly obese (NMO) patients with type 2 diabetes (T2D) after biliopancreatic diversion (BPD). Material and methods: Two groups of T2D patients with different degree of obesity (NMO, 17 cases, BMI 25-35 kg/m2; and morbidly obese [MO], 13 cases, BMI>35 kg/m2) were studied before and at 1 and 5 years after BPD in a university hospital setting. Insulin secretion was assessed by acute insulin response (AIR) to intravenous glucose and by insulinogenic index (IGI). Results: In all MO patients, T2D was remitted or controlled (1 case) at 1 year and results were maintained at 5 years; AIR (μU/mL) and IGI (μU/mg) improved (P

Original languageEnglish
JournalSurgery for Obesity and Related Diseases
DOIs
Publication statusAccepted/In press - Aug 25 2015

Keywords

  • Acute insulin response
  • Bariatric surgery
  • Biliopancreatic diversion
  • Insulinogenic index
  • Obesity degree
  • Type 2 diabetes

ASJC Scopus subject areas

  • Surgery

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