Long-term clinical outcome of primary progressive MS: Predictive value of clinical and MRI data

J. Sastre-Garriga, G. T. Ingle, M. Rovaris, N. Téllez, B. Jasperse, D. R. Altmann, B. Benedetti, V. L. Stevenson, M. Cercignani, S. M. Leary, F. Barkhof, B. Brochet, V. Dousset, M. Filippi, X. Montalban, N. F. Kalkers, C. H. Polman, A. Rovira, D. H. Miller, Alan J. Thompson

Research output: Contribution to journalArticle

Abstract

The authors sought to identify clinical and MRI predictors of outcome in primary progressive multiple sclerosis (PPMS). Clinical and MRI assessments were performed at baseline and 2 and 5 years (clinical only). At baseline, disease duration, expanded disability status scale (EDSS) and brain volume predicted outcome. Adding short-term change variables, baseline EDSS, changes in T2* lesion load and cord area, and number of new lesions were predictive. Clinical and MRI variables predict long-term outcome in PPMS.

Original languageEnglish
Pages (from-to)633-635
Number of pages3
JournalNeurology
Volume65
Issue number4
DOIs
Publication statusPublished - Aug 23 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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    Sastre-Garriga, J., Ingle, G. T., Rovaris, M., Téllez, N., Jasperse, B., Altmann, D. R., Benedetti, B., Stevenson, V. L., Cercignani, M., Leary, S. M., Barkhof, F., Brochet, B., Dousset, V., Filippi, M., Montalban, X., Kalkers, N. F., Polman, C. H., Rovira, A., Miller, D. H., & Thompson, A. J. (2005). Long-term clinical outcome of primary progressive MS: Predictive value of clinical and MRI data. Neurology, 65(4), 633-635. https://doi.org/10.1212/01.wnl.0000173061.12776.1f