Long-term clinical outcomes of percutaneous coronary intervention for chronic total occlusions in patients with versus without diabetes mellitus

Bimmer E. Claessen; George D. Dangas; Cosmo Godino; Seung Whan Lee; Kotaro Obunai; Mauro Carlino; Jung Won Suh; Martin B. Leon; Carlo Di Mario; Seung Jung Park; Gregg W. Stone; Jeffrey W. Moses; Antonio Colombo; Roxana Mehran

doi:10.1016/j.amjcard.2011.05.021

Long-term clinical outcomes of percutaneous coronary intervention for chronic total occlusions in patients with versus without diabetes mellitus

Bimmer E. Claessen, George D. Dangas, Cosmo Godino, Seung Whan Lee, Kotaro Obunai, Mauro Carlino, Jung Won Suh, Martin B. Leon, Carlo Di Mario, Seung Jung Park, Gregg W. Stone, Jeffrey W. Moses, Antonio Colombo, Roxana Mehran

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

There is a paucity of data on long-term outcomes after percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) in the high-risk group of patients with diabetes mellitus (DM). The aim of this study was to evaluate long-term clinical outcomes after PCI of CTOs in patients with and without DM. A total of 1,742 patients with known DM status underwent PCI of CTOs at 3 tertiary care centers in the United States, South Korea, and Italy from 1998 to 2007. Five-year clinical outcomes were evaluated in patients with successful versus failed CTO PCI and the use of drug-eluting stents (DES) versus bare-metal stents (BMS) stratified according to DM status. A total of 395 patients (23%) had DM (42% of whom had insulin-dependent DM). Procedural success was similar in patients with versus without DM (69.6% vs 67.9%, p = 0.53). After successful CTO PCI, stents were implanted in 96.4% of patients with DM (BMS in 23.8%, DES in 76.2%) and in 94.0% of patients without DM (BMS in 38.6%, DES in 61.4%). Median follow-up was 3.0 years. In patients with DM, successful CTO PCI was associated with reduced long-term mortality (10.4% vs 13.0%, p

Original language	English
Pages (from-to)	924-931
Number of pages	8
Journal	The American Journal of Cardiology
Volume	108
Issue number	7
DOIs	https://doi.org/10.1016/j.amjcard.2011.05.021
Publication status	Published - Oct 1 2011

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.amjcard.2011.05.021

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Claessen, B. E., Dangas, G. D., Godino, C., Lee, S. W., Obunai, K., Carlino, M., Suh, J. W., Leon, M. B., Di Mario, C., Park, S. J., Stone, G. W., Moses, J. W., Colombo, A., & Mehran, R. (2011). Long-term clinical outcomes of percutaneous coronary intervention for chronic total occlusions in patients with versus without diabetes mellitus. The American Journal of Cardiology, 108(7), 924-931. https://doi.org/10.1016/j.amjcard.2011.05.021

Claessen, BE, Dangas, GD, Godino, C, Lee, SW, Obunai, K, Carlino, M, Suh, JW, Leon, MB, Di Mario, C, Park, SJ, Stone, GW, Moses, JW, Colombo, A & Mehran, R 2011, 'Long-term clinical outcomes of percutaneous coronary intervention for chronic total occlusions in patients with versus without diabetes mellitus', The American Journal of Cardiology, vol. 108, no. 7, pp. 924-931. https://doi.org/10.1016/j.amjcard.2011.05.021

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title = "Long-term clinical outcomes of percutaneous coronary intervention for chronic total occlusions in patients with versus without diabetes mellitus",

abstract = "There is a paucity of data on long-term outcomes after percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) in the high-risk group of patients with diabetes mellitus (DM). The aim of this study was to evaluate long-term clinical outcomes after PCI of CTOs in patients with and without DM. A total of 1,742 patients with known DM status underwent PCI of CTOs at 3 tertiary care centers in the United States, South Korea, and Italy from 1998 to 2007. Five-year clinical outcomes were evaluated in patients with successful versus failed CTO PCI and the use of drug-eluting stents (DES) versus bare-metal stents (BMS) stratified according to DM status. A total of 395 patients (23%) had DM (42% of whom had insulin-dependent DM). Procedural success was similar in patients with versus without DM (69.6% vs 67.9%, p = 0.53). After successful CTO PCI, stents were implanted in 96.4% of patients with DM (BMS in 23.8%, DES in 76.2%) and in 94.0% of patients without DM (BMS in 38.6%, DES in 61.4%). Median follow-up was 3.0 years. In patients with DM, successful CTO PCI was associated with reduced long-term mortality (10.4% vs 13.0%, p ",

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AU - Claessen, Bimmer E.

AU - Dangas, George D.

AU - Godino, Cosmo

AU - Lee, Seung Whan

AU - Obunai, Kotaro

AU - Carlino, Mauro

AU - Suh, Jung Won

AU - Leon, Martin B.

AU - Di Mario, Carlo

AU - Park, Seung Jung

AU - Stone, Gregg W.

AU - Moses, Jeffrey W.

AU - Colombo, Antonio

AU - Mehran, Roxana

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Long-term clinical outcomes of percutaneous coronary intervention for chronic total occlusions in patients with versus without diabetes mellitus

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