Abstract
Controversy still exists in medical literature about the best type of long-term steroid regimen. On the hypothesis that the antiinflammatory effects of steroids persist longer than the undesirable metabolic effects, the administration in a single-morning dose has been proposed to reduce adrenal suppression by mimicking the endogenous circadian rhythm. However, little information is available about the optimal interval between doses. Harter suggested a 48-hr interval for prednisone, since a 24-hr interval was accompanied by adrenal suppression and a 72-hr interval was therapeutically ineffective. On the other hand, a lower level of immunosuppression was reported using delayed hypersensitivity as an index in patients on alternate-day (AD) prednisone therapy. To evaluate the effects of a single-morning daily (D) or AD dose of prednisone in cadaver kidney transplant recipients, we compared two randomized groups of patients with stable renal function during a follow-up period of up to 5 years.
Original language | English |
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Pages (from-to) | 327-330 |
Number of pages | 4 |
Journal | Transplantation Proceedings |
Volume | 12 |
Issue number | 2 |
Publication status | Published - 1980 |
ASJC Scopus subject areas
- Surgery
- Transplantation