Long-term continuous intraperitoneal insulin treatment in brittle diabetes

G. Pozza, D. Spotti, P. Micossi, M. Cristallo, M. Melandri, P. M. Piatti, L. D. Monti, A. E. Pontiroli

Research output: Contribution to journalArticle

Abstract

Attempts to achieve a fair metabolic equilibrium in a young woman with brittle diabetes by continuous subcutaneous, intramuscular, and continuous intravenous administration of insulin were unsuccessful. Continuous intraperitoneal administration of insulin through a permanently inserted polyethylene catheter connected to an open-loop peristaltic pump led to an appreciable improvement in mean blood glucose concentration, mean amplitude of glycaemic excursions, and M value and to normalisation of intermediate metabolic products. The peritoneal catheter was well tolerated for over 120 days without appreciable adverse effects. This case suggests that long-term intraperitoneal administration of insulin is a feasible therapeutic approach in the management of brittle diabetes.

Original languageEnglish
Pages (from-to)255-256
Number of pages2
JournalBritish Medical Journal
Volume286
Issue number6361
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Medicine(all)

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