Long-term costs and outcomes in psoriatic arthritis patients not responding to conventional therapy treated with tumour necrosis factor inhibitors: An extension of the Psoriatic Arthritis Cost Evaluation (PACE) study

Ignazio Olivieri, Paolo A. Cortesi, Simona De Portu, Carlo Salvarani, Alberto Cauli, Ennio Lubrano, Antonio Spadaro, Fabrizio Cantini, Roberta Ciampichini, Maria Stefania Cutro, Alessandro Mathieu, Marco Matucci-Cerinic, Leonardo Punzi, Raffaele Scarpa, Lorenzo G. Mantovani

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: Poor information on long-term outcomes and costs on tumour necrosis factor (TNF) inhibitors in psoriatic arthritis (PsA) are available. Our aim was to evaluate long-term costs and benefits of TNF- inhibitors in PsA patients with inadequate response to conventional treatment with traditional disease-modifying anti-rheumatic drugs (tDMARDs). Methods: Fifty-five out of 107 enrolled patients included in the study at one year, completed the 5-year follow-up period. These patients were enrolled in 8 of 9 centres included in the study at one year. Patients aged older than 18 years, with different forms of PsA and failure or intolerance to tDMARDs therapy were treated with anti-TNF agents. Information on resource use, health-related quality of life (HRQoL), disease activity, function and laboratory values were collected at baseline and through the 5 years of therapy. Costs (expressed in Euro 2011) and utility (measured by EQ-5D instrument) before TNF inhibitor therapy and after 1 and 5 years were compared. Results: The majority of patients (46 out of 55; 83.6%) had a predominant or exclusive peripheral arthritis and 16.4% had predominant or exclusive axial involvement. There was a statistically significant improvement of the most important clinical variables after 1 year of follow-up. These improvements were maintained also after 5 years. The direct costs increased by approximately €800 per patient-month after 1 year, the indirect costs decreased by €100 and the overall costs increased by more than €700 per patient-month due to the cost of TNF inhibitor therapy. Costs at 5 year were similar to the costs at 1 year. The HRQoL parameters showed the same trends of the clinical variables. EQ-5D VAS, EQ-5D utility and SF-36 PCS score showed a significant improvement after 1 year, maintained at 5 years. SF-36 MCS showed an improvement only at 5 years. Conclusion: The results of our study suggest that TNF blockers have long-term efficacy. The higher cost of TNF inhibitor therapy was balanced by a significant improvement of HRQoL, stable at 5 years of follow-up. Our results need to be confirmed in larger samples of patients.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalClinical and Experimental Rheumatology
Volume34
Issue number1
Publication statusPublished - 2016

Fingerprint

Psoriatic Arthritis
Tumor Necrosis Factor-alpha
Costs and Cost Analysis
Antirheumatic Agents
Therapeutics
Quality of Life
Arthritis
Cost-Benefit Analysis
Drug Therapy

Keywords

  • Anti-tumour necrosis factor agents
  • Costs
  • Psoriatic arthritis
  • Quality of life

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Long-term costs and outcomes in psoriatic arthritis patients not responding to conventional therapy treated with tumour necrosis factor inhibitors : An extension of the Psoriatic Arthritis Cost Evaluation (PACE) study. / Olivieri, Ignazio; Cortesi, Paolo A.; De Portu, Simona; Salvarani, Carlo; Cauli, Alberto; Lubrano, Ennio; Spadaro, Antonio; Cantini, Fabrizio; Ciampichini, Roberta; Cutro, Maria Stefania; Mathieu, Alessandro; Matucci-Cerinic, Marco; Punzi, Leonardo; Scarpa, Raffaele; Mantovani, Lorenzo G.

In: Clinical and Experimental Rheumatology, Vol. 34, No. 1, 2016, p. 68-75.

Research output: Contribution to journalArticle

Olivieri, I, Cortesi, PA, De Portu, S, Salvarani, C, Cauli, A, Lubrano, E, Spadaro, A, Cantini, F, Ciampichini, R, Cutro, MS, Mathieu, A, Matucci-Cerinic, M, Punzi, L, Scarpa, R & Mantovani, LG 2016, 'Long-term costs and outcomes in psoriatic arthritis patients not responding to conventional therapy treated with tumour necrosis factor inhibitors: An extension of the Psoriatic Arthritis Cost Evaluation (PACE) study', Clinical and Experimental Rheumatology, vol. 34, no. 1, pp. 68-75.
Olivieri, Ignazio ; Cortesi, Paolo A. ; De Portu, Simona ; Salvarani, Carlo ; Cauli, Alberto ; Lubrano, Ennio ; Spadaro, Antonio ; Cantini, Fabrizio ; Ciampichini, Roberta ; Cutro, Maria Stefania ; Mathieu, Alessandro ; Matucci-Cerinic, Marco ; Punzi, Leonardo ; Scarpa, Raffaele ; Mantovani, Lorenzo G. / Long-term costs and outcomes in psoriatic arthritis patients not responding to conventional therapy treated with tumour necrosis factor inhibitors : An extension of the Psoriatic Arthritis Cost Evaluation (PACE) study. In: Clinical and Experimental Rheumatology. 2016 ; Vol. 34, No. 1. pp. 68-75.
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abstract = "Objective: Poor information on long-term outcomes and costs on tumour necrosis factor (TNF) inhibitors in psoriatic arthritis (PsA) are available. Our aim was to evaluate long-term costs and benefits of TNF- inhibitors in PsA patients with inadequate response to conventional treatment with traditional disease-modifying anti-rheumatic drugs (tDMARDs). Methods: Fifty-five out of 107 enrolled patients included in the study at one year, completed the 5-year follow-up period. These patients were enrolled in 8 of 9 centres included in the study at one year. Patients aged older than 18 years, with different forms of PsA and failure or intolerance to tDMARDs therapy were treated with anti-TNF agents. Information on resource use, health-related quality of life (HRQoL), disease activity, function and laboratory values were collected at baseline and through the 5 years of therapy. Costs (expressed in Euro 2011) and utility (measured by EQ-5D instrument) before TNF inhibitor therapy and after 1 and 5 years were compared. Results: The majority of patients (46 out of 55; 83.6{\%}) had a predominant or exclusive peripheral arthritis and 16.4{\%} had predominant or exclusive axial involvement. There was a statistically significant improvement of the most important clinical variables after 1 year of follow-up. These improvements were maintained also after 5 years. The direct costs increased by approximately €800 per patient-month after 1 year, the indirect costs decreased by €100 and the overall costs increased by more than €700 per patient-month due to the cost of TNF inhibitor therapy. Costs at 5 year were similar to the costs at 1 year. The HRQoL parameters showed the same trends of the clinical variables. EQ-5D VAS, EQ-5D utility and SF-36 PCS score showed a significant improvement after 1 year, maintained at 5 years. SF-36 MCS showed an improvement only at 5 years. Conclusion: The results of our study suggest that TNF blockers have long-term efficacy. The higher cost of TNF inhibitor therapy was balanced by a significant improvement of HRQoL, stable at 5 years of follow-up. Our results need to be confirmed in larger samples of patients.",
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T2 - An extension of the Psoriatic Arthritis Cost Evaluation (PACE) study

AU - Olivieri, Ignazio

AU - Cortesi, Paolo A.

AU - De Portu, Simona

AU - Salvarani, Carlo

AU - Cauli, Alberto

AU - Lubrano, Ennio

AU - Spadaro, Antonio

AU - Cantini, Fabrizio

AU - Ciampichini, Roberta

AU - Cutro, Maria Stefania

AU - Mathieu, Alessandro

AU - Matucci-Cerinic, Marco

AU - Punzi, Leonardo

AU - Scarpa, Raffaele

AU - Mantovani, Lorenzo G.

PY - 2016

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N2 - Objective: Poor information on long-term outcomes and costs on tumour necrosis factor (TNF) inhibitors in psoriatic arthritis (PsA) are available. Our aim was to evaluate long-term costs and benefits of TNF- inhibitors in PsA patients with inadequate response to conventional treatment with traditional disease-modifying anti-rheumatic drugs (tDMARDs). Methods: Fifty-five out of 107 enrolled patients included in the study at one year, completed the 5-year follow-up period. These patients were enrolled in 8 of 9 centres included in the study at one year. Patients aged older than 18 years, with different forms of PsA and failure or intolerance to tDMARDs therapy were treated with anti-TNF agents. Information on resource use, health-related quality of life (HRQoL), disease activity, function and laboratory values were collected at baseline and through the 5 years of therapy. Costs (expressed in Euro 2011) and utility (measured by EQ-5D instrument) before TNF inhibitor therapy and after 1 and 5 years were compared. Results: The majority of patients (46 out of 55; 83.6%) had a predominant or exclusive peripheral arthritis and 16.4% had predominant or exclusive axial involvement. There was a statistically significant improvement of the most important clinical variables after 1 year of follow-up. These improvements were maintained also after 5 years. The direct costs increased by approximately €800 per patient-month after 1 year, the indirect costs decreased by €100 and the overall costs increased by more than €700 per patient-month due to the cost of TNF inhibitor therapy. Costs at 5 year were similar to the costs at 1 year. The HRQoL parameters showed the same trends of the clinical variables. EQ-5D VAS, EQ-5D utility and SF-36 PCS score showed a significant improvement after 1 year, maintained at 5 years. SF-36 MCS showed an improvement only at 5 years. Conclusion: The results of our study suggest that TNF blockers have long-term efficacy. The higher cost of TNF inhibitor therapy was balanced by a significant improvement of HRQoL, stable at 5 years of follow-up. Our results need to be confirmed in larger samples of patients.

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